by Jennifer Brown, University of Iowa Graphical abstract. Credit: Redox Biology (2024). DOI: 10.1016/j.redox.2024.103375 Results from a randomized, phase 2 clinical trial show that adding high-dose, intravenous (IV) vitamin C to chemotherapy doubles the overall survival of patients with late-stage metastatic pancreatic cancer from eight months to 16 months. “This is a deadly disease with very poor outcomes...
Tag: <span>Chemotherapy</span>
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One man’s mission to revive a forgotten, life-saving cancer drug
Dutch immunologist Jacques Neefjes believes the drug aclarubicin, unavailable in Europe for 20 years, could have helped 100,000 people with a rare blood cancer Eva AmsenSat 27 Jul 2024 12.00 EDT For the past decade, the Dutch immunologist Jacques (Sjaak) Neefjes has been on a mission to bring back a cancer drug that hasn’t been...
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Researchers discover new pathway to cancer cell death from chemotherapy
MAY 16, 2024 by Netherlands Cancer Institute Organoid of a patient with colon cancer, treated (right) and not treated with the chemotherapy etoposide. The treatment causes DNA damage and a reduction in protein synthesis. This triggers a stress signal that causes the cells to die. Orange: marker for DNA damage. Green: marker for protein synthesis....
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A noninvasive treatment for “chemo brain”
Stimulating gamma brain waves may protect cancer patients from memory impairment and other cognitive effects of chemotherapy. Anne Trafton | MIT News Patients undergoing chemotherapy often experience cognitive effects such as memory impairment and difficulty concentrating — a condition commonly known as “chemo brain.” MIT researchers have now shown that a noninvasive treatment that stimulates gamma frequency...
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Chemotherapy brain fog cleared with simple light and sound treatment
By Michael Irving MIT scientists have shown in mice that a simple light and sound exposure therapy can reduce symptoms of ‘chemo brain,’ the cognitive issues that arise during chemotherapy Depositphotos If you or someone you know has gone through chemotherapy, you might be familiar with the side effect commonly called ‘chemo brain.’ Scientists have...
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Why leukemic stem cells not harmed by chemotherapy begin to grow and produce AML cells after treatment
by University of Birmingham AML-subtype specific gene expression and chromatin accessibility is established in LSCs. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-45691-4The mystery of why myeloid leukemia starts to grow again after chemotherapy has killed the bulk of malignant cells, and how growth may be blocked by repurposed drugs, has potentially been solved through new research. The...
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Chemotherapy becomes more efficient when senescent cells are eliminated by immunotherapy, shows study
by Institute for Research in Biomedicine (IRB Barcelona) Senescent human melanoma tumor cells. In brown, the PD-L2 protein acts as a protective shield and prevents the action of the immune system. Credit: IRB BarcelonaCancer treatments, including chemotherapy, in addition to killing a large number of tumor cells, also result in the generation of senescent tumor cells...
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Common chemotherapy drugs don’t work like doctors thought, with big implications for drug discovery
by Will Cushman, University of Wisconsin-Madison A cancer cell undergoing abnormal mitosis and dividing into three new cells rather than two following treatment with a microtubule poison. Credit: Beth Weaver, University of Wisconsin–Madison A new study from the University of Wisconsin–Madison suggests that chemotherapy may not be reaching its full potential, in part because researchers and...
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Natural sugar induces “honeybee syndrome” in cancer to boost chemotherapy
By Michael Irving July 18, 2023 Scientists have found that triggering “honeybee syndrome” could be an effective secondary treatment against cancer Depositphotos Scientists have discovered that a common natural sugar could play a role in boosting cancer treatments like chemotherapy. Mannose was found to be able to invoke “honeybee syndrome” in cancer cells to slow...
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A step toward treating chemotherapy-resistant prostate cancer
AMERICAN CHEMICAL SOCIETY Prostate cancer is a leading cause of death among American men, and it’s resistant to one of the most powerful chemotherapy medications — cisplatin. Now, researchers reporting in ACS Central Science have developed the first therapy of its kind that disrupts prostate cancer cells’ metabolism and releases cisplatin into the weakened cells,...