NEWS RELEASE 3-JUN-2024 Peer-Reviewed PublicationUNIVERSITY OF EASTERN FINLAND Treatment resistance caused by cancer cell plasticity constitutes a major challenge in the treatment of prostate cancer. Published in Nucleic Acids Research, a recent study from the University of Eastern Finland Institute of Biomedicine suggests that the SIX2 protein may be a possible factor underlying increased plasticity...
Tag: <span>Chromatin</span>
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Study finds that special filters in glasses can help the color blind see colors better
Effect persists even when glasses are not worn UNIVERSITY OF CALIFORNIA – DAVIS HEALTH JOHN S. WERNER OF UC DAVIS HEALTH HAS LED A STUDY OF GLASSES WITH SPECIAL FILTERS DESIGNED TO ADDRESS COLORBLINDNESS. view more CREDIT: UC REGENTS / UC DAVIS HEALTH A new UC Davis Eye Center study, conducted in collaboration with France’s...
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How the immune system generates a vast antibody repertoire to fight infections
by Research Institute of Molecular Pathology It has long been known that the acquired immune system can generate a vast antibody (immunoglobulin) repertoire by gene recombination in developing B-cells. However, it was not understood how the different immunoglobulin gene segments can meet each other in the three-dimensional space of a B-cell nucleus to undergo recombination,...
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Chromatin organizes into 3D ‘forests’ in single cells
A single cell contains the genetic instructions for an entire organism. This genomic information is managed and processed by the complex machinery of chromatin — a mix of DNA and protein in chromosomes whose function and role in disease are of increasing interest to scientists and engineers. Using mathematical modeling and optical imaging, researchers funded...
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Study reveals more about how immune cells create new types of antibodies
by Bob Yirka , Medical Xpress A team of researchers at Boston Children’s Hospital has learned more about the process of V(D)J recombination and how it makes use of chromatin looping to collect segments that are to be spliced. In their paper published in the journal Nature, the researchers outline their research and what they...
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For the first time, researchers control cells’ chromatin to prevent cancer from adapting to treatment
Northwestern Engineering’s Vadim Backman has developed an effective new strategy for treating cancer, which has wiped out the disease to near completion in cellular cultures in the laboratory. The treatment works by controlling chromatin, a group of macromolecules—including DNA, RNA, and proteins—that houses genetic information within cells and determines which genes get suppressed or expressed. In the case of cancer,...