by Broad Institute of MIT and Harvard Credit: CC0 Public DomainBy analyzing millions of small genetic differences across a person’s genome, researchers can calculate a polygenic risk score to estimate someone’s lifetime odds of developing a certain disease. Over the past decade, scientists have developed these risk scores for dozens of diseases, including heart disease, kidney...
by David DeFusco, University of North Carolina at Chapel Hill School of Medicine Spatiotemporal on-demand patch for wireless, active control of drug delivery. a Schematic illustration highlighting the construction of a wirelessly controlled spatiotemporal on-demand patch (SOP) for high-precision drug delivery. The SOP features two main components: (i) an array of drug-loaded microneedles protected by active...
By Elaine Chen and Isabella Cueto Dec. 29, 2022 CHRISTINE KAO/STAT The very term “chronic disease” might imply that little changes — or improves — over time. But there is a lot percolating on the chronic disease front, from the mysterious (long Covid) to well-known problems. For the millions of people in the United States who...
by University of South Australia Credit: Unsplash/CC0 Public Domain In a world first discovery, South Australian researchers have identified a genetic mutation responsible for a lymphatic disorder that may cause stillbirth or severe, chronic disease in affected children. An anomaly in the development of lymphatic vessels in unborn children, leading to fluid accumulating in the...
A trifling paper cut is a site of frenzied activity. Within it, a squad of epidermal stem cells briskly regenerate to patch up the wound. A closer inspection of this war-torn swath of epidermis will reveal that, while some of the stem cells are native to the area, others are newcomers—former hair-producing stem cells that,...
UNIVERSITY OF CALIFORNIA – SAN FRANCISCO Scientists at UC San Francisco are learning how immune cells naturally clear the body of defunct – or senescent – cells that contribute to aging and many chronic diseases. Understanding this process may open new ways of treating age-related chronic diseases with immunotherapy. In a healthy state, these immune...
For decades, poor medication adherence has been recognized as a significant and persistent problem in the healthcare system. Since a report published in 2000 by the U.S. Department of Health and Human Services, numerous studies have shown that up to 50% of patients exhibit varying degrees of non-adherence and non-persistence. Poor adherence and persistence contribute...
Older adults with low vitamin K had higher death risk over 13 years compared to those with adequate vitamin K levels TUFTS UNIVERSITY, HEALTH SCIENCES CAMPUS BOSTON (June 15, 2020)– A new, multi-ethnic study found older adults with low vitamin K levels were more likely to die within 13 years compared to those whose vitamin...
by Murdoch University Researchers at the Australian National Phenome Centre at Murdoch University and partners at Imperial College London have made a major breakthrough in understanding how individuals can have different reactions to the same diets. For decades, nutritionists and scientists have been debating whether weight loss is down to sheer will power and healthiness...
An experimental drug that has been shown to improve the function of diseased and aged mitochondria binds to 12 key proteins involved in energy production, researchers at the University of Washington School of Medicine have found. The drug, elamipretide, also called SS-31, has shown promise for treating rare inherited diseases that affect the mitochondria, the...
