THC-P, also known by its more scientific name – tetrahydrocannabiphorol, is a type of natural cannabinoid which is similar to THC and is found in extremely low concentrations in the cannabis plant. The potential of THC-P is considered to be 33 times more active than that of THC. Therefore, it is quite unique. THC-P is...
Tag: <span>chronic pain</span>
Post
Could monoclonal antibodies replace opioids for chronic pain?
by UC Davis A model of a complex protein that may fit into nerve channels and stop the transmission of pain. Credit: Phuong Tran Nguyen, UC Davis During the pandemic, physicians used infusions of monoclonal antibodies—antibodies made in a lab—to help patients fight off COVID-19 infections. Now, researchers at UC Davis are trying to create...
Post
Old anti-psychotic drug reveals new treatment pathway for chronic pain
By Rich Haridy September 05, 2022 Research has revealed fluphenazine lowers levels of a metabolite linked to chronic pain signaling Depositphotos A new study has found an old antipsychotic drug blocks a signaling pathway that has been linked to chronic neuropathic pain. The surprising findings not only point to novel future treatments for pain but...
Post
Study finds that sound plus electrical body stimulation has potential to treat chronic pain
by University of Minnesota A University of Minnesota Twin Cities-led team has found that electrical stimulation of the body combined with sound activates the brain’s somatosensory cortex, increasing the potential for using the technique to treat chronic pain and other sensory disorders. Credit: SONIC Lab, University of Minnesota A University of Minnesota Twin Cities-led team...
Post
Elucidating the molecular targets of “eicosapentaenoic acid”: A natural remedy for chronic pain
OKAYAMA UNIVERSITY IMAGE: NEW STUDY IDENTIFIES VESICULAR NUCLEOTIDE TRANSPORTER AS A NOVEL TARGET OF EICOSAPENTAENOIC ACID (EPA) AND HIGHLIGHTS THE MECHANISM UNDERLYING THE ANALGESIC EFFECT OF EPA. EPA POTENTLY ATTENUATES NEUROPATHIC AND INFLAMMATORY PAIN AND INSULIN RESISTANCE, WITH FEWER SIDE EFFECTS CREDIT: TAKAAKI MIYAJI FROM OKAYAMA UNIVERSITY Eicosapentaenoic acid (EPA) is an essential nutrient belonging...
Post
Discovery of gene involved in chronic pain creates new treatment target
by University of Oxford Clinical wind-up ratio is associated with SLC8A3/NCX3. (A) Clinical wind-up ratio (WUR) was performed over the mid ventral forearm using a 255-mN von Frey hair and recording a pain rating for a single stimulus followed by a series of 10 stimuli. (B) Boxplots of numerical pain ratings for the single stimulus...
Post
Cannabis-related products demonstrate short-term reduction in chronic pain
by Oregon Health & Science University Credit: Unsplash/CC0 Public Domain Evidence behind the effectiveness of cannabis-related products to treat chronic pain is surprisingly thin, according to a new systematic evidence review by researchers at Oregon Health & Science University. The federally funded review, which will be updated on an ongoing basis, was published today in...
Post
In radical claim, study suggests inflammation wards off chronic pain instead of causing it
By Jason Mast May 11, 2022 ADOBE For two decades, Luda Diatchenko investigated the underlying biology of pain like a detective chasing clue after clue: What role does this gene play? How about that protein? She always wondered, though, what she would find if she could look at how every gene inside a cell behaves...
Post
Discovery in the brains of army veterans with chronic pain could pave way for personalized treatments
by Frontiers Credit: Pixabay/CC0 Public Domain A new study is the first to investigate brain connectivity patterns at rest in veterans with both chronic pain and trauma, finding three unique brain subtypes potentially indicating high, medium, and low susceptibility to pain and trauma symptoms. The findings provide an objective measurement of pain and trauma susceptibility...
Post
How chronic pain arises
HEIDELBERG UNIVERSITY IMAGE: SECTION OF MOUSE DORSAL HORN SPINAL CORD. BLUE MARKS CELL NUCLEI, RED THE NEURONS. GREEN HIGHLIGHTS THE ACETYLATION LEVEL OF HISTONE 3, USED TO MEASURE THE ACTIVITY OF HDAC4. CREDIT: DANIELA MAUCERI One epigenetic factor as well as one organic anion transporter (OAT1), whose function in the nervous system was hitherto unknown,...