Miriam E. Tucker July 13, 2023 Should pharmacologic treatment of type 2 diabetes start with combination therapy or metformin monotherapy, adding other agents over time? This question was debated at the recent American Diabetes Association 83rd Scientific Sessions by two well-known clinician-researchers in the diabetes world. Ralph A. DeFronzo, MD, argued for combination therapy at the time of diagnosis,...
Tag: <span>combination therapy</span>
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Debate Continues on Combination Therapy for Hypothyroidism
Miriam E. Tucker May 20, 2022 It’s “critically important” for clinicians to recognize that not all patients with hypothyroidism are fully treated with levothyroxine (LT4) and some may need combination treatment with triiodothyronine (LT3) despite normal levels of thyroid stimulating hormone (TSH), according to thyroid expert Antonio C. Bianco, MD, PhD. Speaking to a crowded room at...
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Triple combination therapy brings lasting improvement in cystic fibrosis
CHARITÉ – UNIVERSITÄTSMEDIZIN BERLIN IMAGE: COMBINATION THERAPY INVOLVING THREE DRUGS – ELEXACAFTOR, TEZACAFTOR, AND IVACAFTOR – MAKES THE MUCUS IN THE AIRWAYS OF CYSTIC FIBROSIS PATIENTS (SHOWN IN GREEN IN THE FIGURE ABOVE) LESS THICK AND STICKY. THIS MAKES IT EASIER FOR THE LUNGS TO CLEAR BACTERIA, AND THERE ARE FEWER RESPIRATORY INFLAMMATION CELLS. CREDIT:...
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SMART researchers discover novel combination therapy to counter antibiotic-resistant Mycobacterium abscessus infections
SINGAPORE-MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY (SMART) IMAGE: SMART AMR RESEARCHERS PEIYING HO, SHARON LING, BOON CHONG GOH, AND PATRINA CHUA (FROM LEFT TO RIGHT) PERFORMED COMPOUND SCREENING TO IDENTIFY NOVEL ANTIBIOTIC COMBINATIONS. CREDIT: SMART AMR Singapore, 6 June 2023 – Researchers from the Antimicrobial Resistance (AMR) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s...
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Researchers develop novel combination therapy for treating vancomycin-resistant bacteria
by Singapore-MIT Alliance for Research and Technology A confocal microscopy image of macrophages treated with MTX (cyan) that have eaten bacteria (magenta). Credit: Singapore-MIT Alliance for Research and Technology (SMART) Researchers have developed a novel combination therapy using an anticancer agent, mitoxantrone (MTX), together with an antibiotic, vancomycin, for treating bacteria that are resistant to the vancomycin, which...
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In vivo self-assembled siRNA as a modality for combination therapy of ulcerative colitis
by Nanjing University School of Life Sciences Evaluation of the activity of TNF-α siRNA-encapsulating sEVs in an ex vivo model. a Schematic of the experimental design. Acute UC was induced in male BALB/c mice by replacing their drinking water with a 2.5% DSS solution for 7 days. DSS mice were intravenously injected with 5 mg/kg CMV-scrR...
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New effective combination therapy for paediatric T-acute leukaemia
TAMPERE UNIVERSITY Acute lymphoblastic leukaemia (ALL) is the most common cancer affecting children. The T-ALL form of leukaemia that emerges from early T lineage cells has a poorer prognosis than B-lineage ALL. The prognosis for relapsed T-ALL is very poor and new therapies are sorely needed. A joint study by Tampere University’s Faculty of Medicine...
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Combination therapy reduces toxic aggregates in Parkinson’s disease
by Will Doss, Northwestern University Endoplasmic reticulum (red) is small and malformed in Parkinson’s disease (left), but can be rescued with diltiazem and a farnesyl-transferase inhibitor (right). Credit: Northwestern University A new combination of drugs could fix the broken lysosomal enzyme pathway in Parkinson’s disease-afflicted brain cells, according to a Northwestern Medicine study published in Neuron. Improving...
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Hypoxia imaging and combination therapy aid immunotherapy treatment of solid tumors
UNIVERSITY OF ALABAMA AT BIRMINGHAM IMAGE: BEN LARIMER CREDIT: UAB BIRMINGHAM, Ala. – Immunotherapy using checkpoint inhibitors can work well to treat cancer, but only a minority of patients respond to therapy. Researchers at the University of Alabama at Birmingham have now shown — in preclinical experiments — how to identify non-responding tumors and improve their response to...
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A potential combination therapy for brain metastases of breast cancer
by Ludwig Institute for Cancer Research Credit: Unsplash/CC0 Public Domain A Ludwig Cancer Research study has identified and preclinically validated combination treatments for the brain metastases of breast cancer, a common and typically lethal manifestation of the malignancy. The combination therapy, reported in the current issue of Nature Cancer, targets tumor-associated macrophages and microglia (TAMs), immune cells...
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