RNA-targeting CRISPR reveals that hundreds of noncoding RNAs are essential—not “junk”—including in human development and cancerPeer-Reviewed Publication New York University Genes contain instructions for making proteins, and a central dogma of biology is that this information flows from DNA to RNA to proteins. But only two percent of the human genome actually encodes proteins; the function of...
Tag: <span>Crispr</span>
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CRISPR-Cas9 gene editing trial results support further development as treatment for hereditary angioedema
by Amsterdam University Medical Centers Credit: Pixabay/CC0 Public Domain A single treatment with a CRISPR-Cas9 based gene editing therapy is enough to replace the daily medication of patients with hereditary angioedema (HAE), a condition characterized by severe, painful and sudden onset of swelling, sometimes resulting in death. Confirming the findings published earlier this year by researchers...
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Innovative model using CRISPR provides valuable insights into prostate cancer spread
September 23, 2024 by Weill Cornell Medical College Abstract representation of the cancer clonal landscapes in different places in the body, revealing the different clonal architectures. The lines represent some of the trajectories of metastatic cells as they traverse the body. Credit: American Association for Cancer ResearchA new preclinical model using CRISPR, an advanced technology...
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Revolutionizing probiotic therapy: The emergence of CRISPR-Cas engineered strains
by NanJing Agricultural University CRISPR-based genome editing in probiotics. Credit: BioDesign Research Probiotics, defined as live microorganisms beneficial to health, have shown promise in areas like anti-inflammatory activity and brain function, etc. However, challenges remain due to variability in tolerance and colonization among species and strains. Recent advances in genome engineering, including CRISPR-Cas, have facilitated the...
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The ongoing search for an HIV cure: can CRISPR crack the code?
Willow Shah NevilleBy Willow Shah-Neville Photo/ShutterstockHIV CRISPR HIV continues to represent a global health burden, with the World Health Organization (WHO) estimating that, in 2022, there were 39 million people living with the virus. But there is still no effective cure for it. The only option patients have is antiretroviral therapy, which, although it represents...
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Find-and-replace genome editing with CRISPR: A promising therapeutic strategy
by Bar-Ilan University Credit: Pixabay/CC0 Public DomainSevere combined immunodeficiencies (SCIDs) are a group of debilitating primary immunodeficiency disorders, primarily caused by genetic mutations that disrupt T-cell development. SCID can also affect B-cell and natural killer cell function and counts. Left untreated, SCID proves fatal within the first year of life. The conventional treatment for SCID patients...
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AI combined with CRISPR precisely controls gene expression
by New York University Credit: Unsplash/CC0 Public Domain Artificial intelligence can predict on- and off-target activity of CRISPR tools that target RNA instead of DNA, according to new research published in Nature Biotechnology. The study by researchers at New York University, Columbia University, and the New York Genome Center, combines a deep learning model with CRISPR screens to control...
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CRISPR Combined with Glowing Proteins for Viral Detection
MARCH 23RD, 2023 Researchers at Eindhoven University of Technology in the Netherlands have developed a sensitive diagnostic test for viral pathogens that is suitable for use in low-resource regions. The test is based on CRISPR proteins that can detect viral genetic material but also incorporates luciferase proteins, which are bioluminescent proteins that are naturally found...
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Using CRISPR to detect cancer biomarkers
AMERICAN CHEMICAL SOCIETY Most cancer diagnostic techniques rely on uncomfortable and invasive procedures, such as biopsies, endoscopies or mammograms. Blood samples could be a less unpleasant option, though only a few forms of the disease can currently be diagnosed this way. But now, researchers reporting in ACS Sensors have developed an easy-to-use method that can detect small amounts of...
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First use of CRISPR to substitute genes to treat patients with cancer
by University of California, Los Angeles CRISPR-associated protein Cas9 (white) from Staphylococcus aureus based on Protein Database ID 5AXW. Credit: Thomas Splettstoesser (Wikipedia, CC BY-SA 4.0) For the first time, scientists have used CRISPR technology to insert genes that allow immune cells to focus their attack on cancer cells, potentially leaving normal cells unharmed and increasing...