by Johns Hopkins University School of Medicine Schematic summary of RAAS pathway. Credit: Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2401968121 As part of the COVID-19 International Research Team, researchers at the Johns Hopkins Kimmel Cancer Center, Children’s Hospital of Philadelphia, the University of Pittsburgh and Weill Cornell Medicine discovered a novel cause of cytokine storm—the...
Tag: <span>cytokine</span>
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Researchers reveal molecular mechanism of cytokine storm induced by coronavirus
by Zhang Nannan, Chinese Academy of Sciences SARS-CoV-2 stabilizes host mRNAs to induce cytokine storm. Credit: Xue Yuanchao’s groupIn the past four years, the pathogen responsible for Coronavirus Disease 2019 (COVID-19), SARS-CoV-2, has infected more than 770 million people and caused more than 6.9 million deaths worldwide. The severe impact of SARS-CoV-2 is often attributed to...
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Scientists discover a novel mechanism leading to the inflammatory cytokine storm in COVID-19
by Hospital for Special Surgery IFN-I response associated with pDCs precedes inflammatory response in macrophages from BAL fluids and lungs of patients with COVID-19. (A) Abundance of pDCs depending on disease state in BAL from DOI:10.1038/s41591-020-0901-9. (B) Abundance of IFN-I response for pDCs aggregated by disease state in BAL. (C) Inference of a pseudotime axis using...
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Cytokine increases production of ‘beige fat’ to burn more cellular energy
by Public Library of Science Credit: CC0 Public Domain An immune signal promotes the production of energy-burning “beige fat,” according to a new study publishing August 5th in the open-access journal PLOS Biology by Zhonghan Yang of Sun Yat-Sen University, Guangzhou, China, and colleagues. The finding may lead to new ways to reduce obesity and treat metabolic disorders. The...
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Mice treated with this cytokine lose weight by ‘sweating’ fat
by Perelman School of Medicine at the University of Pennsylvania Credit: CC0 Public Domain Treating obese mice with the cytokine known as TSLP led to significant abdominal fat and weight loss compared to controls, according to new research published Thursday in Science from researchers in the Perelman School of Medicine at the University of Pennsylvania. Unexpectedly,...
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Designer cytokine makes paralyzed mice walk again
RUHR-UNIVERSITY BOCHUM The researchers published their report in the Journal Nature Communications from 15 January 2021. When the communication breaks down Spinal cord injuries caused by sports or traffic accidents often result in permanent disabilities such as paraplegia. This is caused by damage to nerve fibers, so-called axons, which carry information from the brain to the muscles and back...
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Does the COVID-19 cytokine storm exist?
Research may have an impact on the chances of success of a specific treatment RADBOUD UNIVERSITY MEDICAL CENTER Inflammatory proteins, also known as cytokines, play a crucial role in the immune response. If this immune response is too strong, a phenomenon known as “cytokine storm”, it can cause harm to the patient. It has been...
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Dual role discovered for molecule involved in autoimmune eye disease
IL-17, known for driving inflammation, also puts on the brakes, NIH scientists report NIH/NATIONAL EYE INSTITUTE AFTER ACTIVATION THROUGH ITS T-CELL RECEPTOR, TH17 CELLS PRODUCE IL-17A, WHICH BINDS TO ITS OWN RECEPTOR ON THE TH17 CELL. THIS ACTIVATES THE NFΚB PATHWAY. NFΚB DRIVES PRODUCTION OF IL-24,… view more CREDIT: RACHEL CASPI, PH.D. (NEI) The inflammatory...
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Charcoal a weapon to fight superoxide-induced disease, injury
Nanomaterials soak up radicals, could aid treatment of COVID-19 ARTIFICIAL ENZYMES MADE OF TREATED CHARCOAL, SEEN IN THIS ATOMIC FORCE MICROSCOPE IMAGE, COULD HAVE THE POWER TO CURTAIL DAMAGING LEVELS OF SUPEROXIDES. HOUSTON – (July 1, 2020) – Artificial enzymes made of treated charcoal could have the power to curtail damaging levels of superoxides, radical...
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Tuberculosis vaccine strengthens immune system
by University of Bonn A tuberculosis vaccine developed 100 years ago also makes vaccinated persons less susceptible to other infections. While this effect has been recognized for a long time, it is not known what causes it. Together with colleagues from Australia and Denmark, researchers from Radboud university medical center the universities of Nijmegen and...
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