by American College of Physicians Credit: Anne Lowe/public domain Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, reduced the risk for hospitalization for any cause in patients with chronic kidney disease (CKD) with and without type 2 diabetes. The findings suggest that dapagliflozin should be considered in such patients. The study is published in Annals of Internal Medicine....
ERA-EDTA Focal segmental glomerulosclerosis (FSGS) is a rare form of kidney inflammation (glomerulonephritis) in which the glomeruli become increasingly scarred (sclerotic), leading to progressive loss of kidney function. Dysregulation of the immune system plays a role in pathogenesis, which is why immunosuppressive therapy with glucocorticoids can be successful, alongside supportive therapy (especially blocking of the...
The U.S. Food and Drug Administration has granted approval for Farxiga (dapagliflozin) oral tablets to treat adults with heart failure with reduced ejection fraction, the agency announced Tuesday. Farxiga is the first approved sodium-glucose cotransporter 2 inhibitor to treat adults with New York Heart Association functional class II to IV heart failure with reduced ejection...
Chantal Mathieu, M.D., PhD., from the University of Leuven in Belgium, and colleagues assessed continuous glucose monitoring in patients with inadequately controlled type 1 diabetes (hemoglobin A1c [HbA1c] ≥7.7 to ≤11 percent) who received dapagliflozin as an adjunct to adjustable insulin as part of two phase 3 clinical trials. Pooled data included 1,591 patients receiving dapagliflozin 5 mg (530 patients), dapagliflozin 10 mg (529), or placebo (532). The...
