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Study unravels new disease mechanism for monogenic diabetes
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Study unravels new disease mechanism for monogenic diabetes

by King’s College London In this image we can appreciate an organoid (cell nuclei are labeled in blue) with scattered beta-cells (green) and somatostatin cells (red) after the researchers performed their differentiation protocol. This system could be used to explore the effect of specific mutations found in diabetes in the development and functionality of beta-cells....

Skin cells from frontotemporal dementia patients may reveal disease mechanisms and biomarkers for drug research
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Skin cells from frontotemporal dementia patients may reveal disease mechanisms and biomarkers for drug research

by  University of Eastern Finland Fibroblasts of C9-HRE carriers show unaltered C9orf72 levels, express RNA foci, but do not display DPR proteins. a TaqMan assay from fibroblast RNA for C9orf72 all variants. b TaqMan assay from fibroblast RNA for isoform A specific transcript levels. For (a) and (b), data are shown as mean of data points...