USP50 protein helps balance nuclease and helicase activity during critical processes Peer-Reviewed Publication University of Birmingham A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study. In a new paper published in Nature Communications, an international team of researchers have found that the...
Tag: <span>DNA replication</span>
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DAMAGED DNA
All life depends upon DNA repair and replication. In every human cell the essential ability to replicate and repair genomes depends upon the coordinated actions of the genome sequence. Flaws or mistakes in repair and cell cycle regulation can lead to defects in the structure of the DNA and can prevent the replication from functioning...
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Superfast DNA replication causes damage in cancer cells
Inhibitors of PARP proteins are used in cancer treatment. It emerges that PARP inhibitors exert their effect by accelerating DNA replication to a speed at which DNA damage occurs. The two strands of DNA’s double helix unwind to be copied, with a structure called a replication fork forming at the point of separation. The speed...