In the 2020 April 21 issue of Journal of Hepatology, a research group from the Department of Hepatology in Osaka City University Graduate School of Medicine, Japan reported that a new insight into the pathophysiology of human nonalcoholic steatohepatitis (NASH) with fibrosis and suggested a possibility of the new therapy using cytoglobin (CYGB) inducer for...
Tag: <span>DNA</span>
Post
Milestone for the early detection of sepsis
By: LUNGHAMMER – TU GRAZ Whether activating or silencing genes, breaking down defective cells or building new tissue, our body is constantly working to repair itself, even in cases of illness. To fight a disease, our body sends out signals, often long before we ourselves notice the disease. Such signals are, for example, DNA molecules...
Post
CRISPR helps identify potential Alzheimer’s-related protein
by University of Tokyo Experts at the University of Tokyo have identified a new protein in the pathway that leads to Alzheimer’s disease. Researchers used the “molecular scissors” of CRISPR/Cas9 to search for new genes related to the neurodegenerative disease. The exact causes of Alzheimer’s disease remain unknown, but one of the most well-supported theories...
Post
Scientists reveal how proteins team up to repair DNA
New insight on DNA repair in yeast adds to our understanding of why DNA repair processes fail to function properly in disease ELIFE Scientists have revealed an important mechanism in the repair of DNA double-strand breaks, according to new research published today in eLife. The discovery will help our understanding of why DNA repair processes...
Post
Huntington’s disease-causing DNA repeat mutations reversed in the lab
Neurodegenerative diseases, like Huntington’s disease and myotonic dystrophy, are often referred to as DNA repeat diseases, named because of long repeated sequences in the DNA of patients. Increasing repeat expansion length in the affected tissues contribute to earlier age of disease onset and worsen the progression and severity of the disease over time. Graphic portrays...
Post
Jumping genes’ help stabilize DNA folding patterns
Long understood as source of novel genetic traits, jumping genes also provide genomic stability WASHINGTON UNIVERSITY SCHOOL OF MEDICINE “Jumping genes” — bits of DNA that can move from one spot in the genome to another — are well-known for increasing genetic diversity over the long course of evolution. Now, new research at Washington University...
Post
Know thy mitochondria: Autoimmunity to organelles and their DNA
by John Hewitt , Medical Xpress The immune system uses its mitochondria to self-stimulate innate and adaptive responses to infection. Reactive oxygen species (ROS), immunogenic mitochondrial DNA (mtDNA), and even whole mitochondria are locally mobilized in a delicate balance to create hot spots of inflammatory action. When normal limiting feedback on these processes is compromised,...
Post
Your DNA is not your destiny — or a good predictor of your health
New study from the University of Alberta suggests that diseases such as many cancers, diabetes, and Alzheimer’s have a genetic contribution of 5 to 10 per cent at most UNIVERSITY OF ALBERTA In most cases, your genes have less than five per cent to do with your risk of developing a particular disease, according to...
Post
DNA Circuits to Identify Cancer Cells
SIAVASH PARKHIDEH MEDICINE, NANOMEDICINE, ONCOLOGY Researchers from Duke University have developed a new DNA-based tool to identify cancer cells. Their system is a DNA circuit. DNA binding to specific cell markers produces a signal if and only if two specific proteins are present, helping to improve specificity and reduce false positives in cancer cell detection....
Post
Longevity Linked to Proteins That Calm Overexcited Neurons
New research makes a molecular connection between the brain and aging — and shows that overactive neurons can shorten life span. Athousand seemingly insignificant things change as an organism ages. Beyond the obvious signs like graying hair and memory problems are myriad shifts both subtler and more consequential: Metabolic processes run less smoothly; neurons respond less...