August 13, 2024 by Impact Journals, LLC Credit: Pixabay/CC0 Public DomainA new research perspective titled Lipid accumulation drives cellular senescence in dopaminergic neurons has been published in Aging. As highlighted in the Abstract of this perspective, Parkinson’s disease (PD) is an age-related movement disorder caused by the loss of dopaminergic (DA) neurons in the substantia...
by Melissa Rohman, Northwestern University Ca2+ entry through Cav1 Ca2+ channels triggered ER Ca2+ release. (A) Representative reconstruction of a Fura-2–filled SNc dopaminergic neuron (scale bar, 20 μm). (B) Representative whole-cell current clamp recordings (top) and 2PLSM traces of cytosolic Ca2+ oscillations (bottom) in SNc neurons loaded with Fura-2, before and after application of RYR antagonist DHBP. (C and...
