BY JAMES URQUHART 11 JULY 2023 A new drug delivery technique uses synthetic molecular motors to release a drug when activated by visible light. The proof-of-principle delivery mechanism, which was tested on cultured lung cancer cells, could enable a non-invasive, highly controlled and targeted way to activate drugs inside the body. Ben Feringa at the University...
Tag: <span>Drug delivery</span>
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Magnetic microrobots with folate targeting for drug delivery
BEIJING INSTITUTE OF TECHNOLOGY PRESS CO., LTD IMAGE: THE INTRODUCTION OF FA IMPROVED THE TUMOR TARGETING ABILITY OF THE MICROROBOTS, WHICH CAN BE MANIPULATED BY MAGNETIC FIELDS, PRODUCING AN OBVIOUS ANTICANCER EFFECT. CREDIT: CYBORG AND BIONIC SYSTEMS The limited ability of microrobots to assist drugs in entering cells hinders their therapeutic efficacy. To address this,...
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A promising drug delivery method could replace injections with pills
by Baylor College of Medicine Credit: CC0 Public Domain For chronic conditions such as rheumatoid arthritis, treatment often involves lifelong injections. Fear of needles, injection-associated infection and pain are responsible for patients skipping doses, which encourages the development of new delivery strategies that combine efficacy with limited side effects to treat patients adequately. Researchers at Baylor...
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Biological lasso: Enhanced drug delivery to the brain
KANAZAWA UNIVERSITY IMAGE: © 2022 SAKAI, ET AL. (A) A PHARMACOPHORE SEQUENCE OF MET RECEPTOR-BINDING MACROCYCLIC PEPTIDE (AMD4; SHOWN IN RED) WAS INSERTED INTO THE LOOPS (COLOURED BALLS) OF HUMAN IGG1 FC PROTEIN. (B) LASSO-GRAFTING FC YIELDS MET AGONISTS WITH EXTENDED HALF-LIFE IN THE BODY. (C) LASSO-GRAFTING FC OF AN ANTI-TFR ANTIBODY YIELDS MET AGONISTS...
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Drug delivery technology enhances absorption of widely used opioid replacement therapy
by Monash University The main metabolism pathway and metabolites of BUP, including norbuprenorphine, norbuprenorphine glucuronide, and buprenorphine glucuronide. Credit: Frontiers in Pharmacology (2022). DOI: 10.3389/fphar.2022.879660 Monash University researchers have harnessed a new drug delivery technology to allow the oral administration of buprenorphine (BUP), a drug used for severe pain management and opioid replacement therapy. At present BUP...
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Tiny biohybrid robots for intelligent drug delivery
BEIJING INSTITUTE OF TECHNOLOGY PRESS CO., LTD IMAGE: SCIENTISTS FROM BEIJING INSTITUTE OF TECHNOLOGY REVIEWED PROGRESS AND PERSPECTIVES OF BIOHYBRID MICRO- AND NANOROBOTS FOR INTELLIGENT DRUG DELIVERY. CREDIT: JINHUA LI, BEIJING INSTITUTE OF TECHNOLOGY A review paper by scientists at the Beijing Institute of Technology summarized recent advancements in use of intelligent biohybrid micro- and...
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Innovative drug delivery system offers hope for treating genetic diseases
HARVARD UNIVERSITY IMAGE: POSTDOCTORAL FELLOW SAMAGYA BANSKOTA (LEFT) AND GRADUATE STUDENT ADITYA RAGURAM (RIGHT), CO-LEAD AUTHORS, INVESTIGATE IN VIVO DELIVERY OF THERAPEUTIC PROTEINS AT THE LIU LAB. CREDIT: JULIA MCCREARY/ HARVARD GRADUATE STUDENT. A team of researchers led by Harvard and Broad Institute scientists has developed a new drug delivery system using engineered DNA-free virus-like...
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Polymer-coated nanoparticles to promote drug delivery to the brain
INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE – INRS IMAGE: PROFESSOR CHARLES RAMASSAMY AND JEAN-MICHEL RABANEL ANALYZING NANOPARTICLES ON THE NANOSIGHT NS 300, EQUIPMENT OBTAINED THANKS TO THE GENEROSITY OF THE CHARRON FAMILY THROUGH THE ARMAND-FRAPPIER FOUNDATION AS PART OF THE LOUISE & ANDRÉ CHARRON RESEARCH CHAIR ON THE ALZHEIMER’S DISEASE. CREDIT: INRS Treating diseases such...
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Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections
COMPUSCRIPT LTD IMAGE: THE BIORESPONSIVE MICRO-TO-NANO ALBUMIN-BASED SYSTEM WAS ACCUMULATED IN THE LUNGS AND RESPONDS TO THE UPREGULATED MMP-3, THEN TARGETED THE LUNG TISSUE, BRAIN, AND INFECTED MACROPHAGES, REACHING MULTIPLE TARGETS AND EFFICIENT TREATMENT. CREDIT: APSB Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections Just published in the latest issue of Acta...
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Enhancing drug delivery with ultrasound
by Zach Winn, Massachusetts Institute of Technology Credit: CC0 Public Domain It can be difficult to get drugs to disease sites along the gastrointestinal tract, which spans the mouth, esophagus, stomach, small and large intestine, and anus. Invasive treatments can take hours as patients wait for adequate amounts of drugs to be absorbed in the right...
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