by Murdoch University A common pathogenic population of locally proliferating cytotoxic CD8+ LAG3+ TRM T cells with private expanded and unexpanded TCRαβ clonotypes drives keratinocyte-specific cell death across patients with diverse HLA-restricted drug-induced SJS/TEN. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-52990-3 Researchers have identified the skin cells responsible for orchestrating cases of two of the most life-threatening drug reactions. Stevens-Johnson Syndrome (SJS)...
Tag: <span>drug reactions</span>
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Oral antibiotics and risk of serious cutaneous adverse drug reactions
News Release 8-Aug-2024 JAMA Peer-Reviewed PublicationJAMA Network About The Study: Commonly prescribed oral antibiotics are associated with an increased risk of serious cutaneous adverse drug reactions compared with macrolides, with sulfonamides and cephalosporins carrying the highest risk. Prescribers should preferentially use lower-risk antibiotics when clinically appropriate. Corresponding Author: To contact the corresponding author, David N....
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Genetic analysis can reduce adverse drug reactions by 30%
by Karolinska Institutet A credit card-sized card with a magnetic strip containing all the important genetic information. Credit: The Lancet Patients can experience 30% fewer serious adverse reactions if their drugs are tailored to their genes, reports a study published in The Lancet. A European collaboration involving researchers from Karolinska Institutet suggests that a genetic analysis prior...