by Kyoto University A new study led by ASHBi Professor Motoko Yanagita finds the suppression of two molecules, CD153 and CD30, expressed on immune cells mitigates the progression of kidney disease. Credit: Kyoto University Despite nearly two million people dying of acute kidney injury every year, and tens of millions more needing treatment, no effective...
by Vanderbilt University Medical Center Credit: CC0 Public Domain A metabolic enzyme that has been studied in cancer biology and is important for T cell function may offer a new target for anti-inflammatory therapeutics, Vanderbilt researchers have discovered. They report Nov. 11 in the journal Immunity that inhibiting or genetically deleting the enzyme, called MTHFD2,...
by Karolinska Institutet Effects of IL-26 on the activation state of neutrophils exposed to Klebsiella pneumoniae. Human blood neutrophils were exposed to live Klebsiella pneumoniae (multiplicity infection (MOI); 0.01) with and without additional stimulation by rhIL-26 (10 and 50 ng/mL) for 3 hours. The expression of CD11b, CD66b and p38 MAPK was assessed using flow...
by Baylor College of Medicine Credit: CC0 Public Domain Endometriosis is a painful, chronic condition in which tissue from the uterus inappropriately grows outside the uterus. Current treatments are limited and include surgery and hormone therapy, which can involve unwanted side effects. New research conducted by Baylor College of Medicine, the University of Oxford, the University of Wisconsin-Madison...
BOSTON CHILDREN’S HOSPITAL IMAGE: This high-throughput screening system is designed to identify compounds that decrease motor neuron hyperexcitability, a cardinal feature of ALS. Motor neurons derived from patients with ALS are cultured in 384-well plates, and compounds from chemical libraries of small molecules against known molecular targets are added after 3-4 weeks. Live GCaMP imaging,...
By Michael Irving May 26, 2021 Scientists have identified an enzyme in the brain that may protect against damage caused by low oxygen levels Some of the most devastating health effects of a stroke or heart attack are caused by oxygen deprivation in the brain. Now, researchers at Massachusetts General Hospital (MGH) have identified an enzyme that...
