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Study: Opioid drug tolerance develops from interplay of key gene and cholesterol
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Study: Opioid drug tolerance develops from interplay of key gene and cholesterol

by Stacey DeLoye,  University of Florida An “unbiased” screen for genes involved in opioid tolerance relied upon tiny worms called C. elegans. The worm genetics revealed PTCHD1 plays a key role, altering cholesterol in cell membranes. Credit: Scott Wiseman for UF Scripps Biomedical Research. UF Scripps Biomedical Research scientists have a discovered a key gene that...

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Fungal infections: Microbial cooperation leads to drug tolerance

CHARITÉ – UNIVERSITÄTSMEDIZIN BERLIN The treatment of fungal infections is often hampered by fungal pathogens that do not respond, or are tolerant, against anti-fungal drugs. A team of researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have now identified microbial cooperation as one of the causes of this drug tolerance. A collaborative...