by Perelman School of Medicine at the University of Pennsylvania A new study from Penn Medicine lends further evidence that the social behaviors tied to autism spectrum disorders (ASD) emerge from abnormal function of sensory neurons outside the brain. It’s an important finding, published today in the journal Cell Reports, because peripheral sensory systems—which determine...
Tag: <span>Drugs</span>
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Compounds halt SARS-CoV-2 replication by targeting key viral enzyme
by University of South Florida Three configurations of active sites where inhibitor GC-376 binds with the COVID-19 virus’s main protease (drug target Mpro), as depicted by 3D computer modeling. Credit: Image generated by Yu Chen, University of South Florida Health, using X-ray crystallography As the death toll from the COVID-19 pandemic mounts, scientists worldwide continue...
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Coronavirus Discovery: Indigestion and Heartburn Drugs May Increase Chances of COVID-19 by Two-Fold
By Nhx T. Tech Time Until now, scientists are still trying to understand COVID-19 fully to help ensure people’s safety. A new study suggests that popular indigestion and heartburn drugs could increase the risks of getting coronavirus infection. People who take certain indigestion and heartburn medicines are more likely to contract COVID-19. Higher Risk of...
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New forms of ‘red devil’ cancer drug could spare hearts
By Jocelyn KaiserJul. 1, 2020 , 1:20 PM Can the red devil be defanged? Doxorubicin, an old chemotherapy drug that carries this unusual moniker because of its distinctive hue and fearsome toxicity, remains a key treatment for many cancer patients. But a new study reports the drug can be tweaked to reduce its most punishing...
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Electronic decision support tool reduces the risk of overmedication
by Johannes Angerer, Medical University of Vienna As the population ages, the prevalence of chronic disease increases. As a result, more drugs are prescribed. Around 25% of the population aged 65+ are affected by so-called “polypharmacy,” i.e., they regularly take at least five drugs. This results in an increased risk for drug interactions and adverse...
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Study finds drug beneficial for shrinking mesothelioma tumors
by National Cancer Institute A drug that is designed to boost the immune system against mesothelioma, when combined with immunotherapy, was found to be beneficial in a small study involving ten patients. The results, which appeared July 1, 2020, in Science Translational Medicine, suggest that the drug LMB-100 could prolong the life of some patients...
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The combination of four drugs at low doses is more effective in the treatment of a lu
IDIBELL-BELLVITGE BIOMEDICAL RESEARCH INSTITUTE BELLVITGE BIOMEDICAL RESEARCH INSTITUTE (IDIBELL) view more CREDIT: BELLVITGE BIOMEDICAL RESEARCH INSTITUTE (IDIBELL) Inhibit the specific activity of a protein affected by a mutation using high doses of a drug is the usual treatment for many cancers. Despite in the first instance this strategy is effective, leads to treatment resistance development...
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How cancer drugs find their targets
In the watery inside of a cell, complex processes take place in tiny functional compartments called organelles. Energy-producing mitochondria are organelles, as is the frilly golgi apparatus, which helps to transport cellular materials. Both of these compartments are bound by thin membranes. But in the past few years, research at Whitehead Institute and elsewhere has...
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New drug candidate reawakens sleeping HIV in hopes of functional cure
by Sanford Burnham Prebys Medical Discovery Institute Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a next-generation drug called Ciapavir (SBI-0953294) that is effective at reactivating dormant human immunodeficiency virus (HIV). The research, published in Cell Reports Medicine, aims to create a functional HIV cure by activating and then eliminating all pockets of...
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Existing drugs may limit damage caused by HIV
by Yale University Yale researchers have identified four drugs that may help minimize the long-term health effects of HIV infection, they report June 23 in the Journal of Clinical Investigation. Antiretroviral therapy has proved to be a life-saving treatment for those infected with HIV. Yet even after treatment, most patients still harbor latent HIV in...