by Institute of Cancer Research Cancers are often heavily reliant on breaking down fats for their growth and spread, and could be treated by a highly innovative combination of new drugs and dietary changes, a major new study concludes. The landmark research used a surgical ‘iKnife’ to analyze vaporized cancer tissue—and identified a metabolic weakness...
by Luxembourg Institute of Health Researchers at the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH) have developed LIH383, a novel molecule that binds to and blocks a previously unknown opioid receptor in the brain, thereby modulating the levels of opioid peptides produced in the central nervous system (CNS) and potentiating...
by Whitehead Institute for Biomedical Research The molecular structure of the cancer drug cisplatin causes it to concentrate in tiny non-membrane bound organelles called condensates held together by the protein MED1. By altering other drugs to concentrate in specific condensates, drug developers may be able to improve targeting efficacy in future. Credit: Isaac Klein, Whitehead...
The findings provide a clear path to uncovering new drugs to control addiction, pain and neurological disorders such as epilepsy and muscle spasticity CREDIT: (ILLUSTRATION BY YEKATERINA KADYSHEVSKAYA/BRIDGE INSTITUTE AT THE USC MICHELSON CENTER FOR CONVERGENT BIOSCIENCE.) As the body goes about its daily business, molecules called neurotransmitters control the level of electrical activity within...
A new study that looks closely at the cardiac health of flies provides new evidence that liver dysfunction may lead to deterioration of the heart. The research fills in gaps in how scientists understand the links between heart health and other tissues and could inform the development of new therapies in human medicine, said Hua...
Controlling dopamine signalling by targeting the histamine receptor has been shown to be a promising strategy for preventing the progression of Huntington’s disease in mice Scientists have described a potential new therapeutic strategy for slowing down early-stage Huntington’s disease in a new study published today in eLife. The research in mice indicates that targeting the...
by University of Michigan For children and young adults with Crohn’s disease, steroid-sparing therapies may help reduce the risk of developing a severe and common complication of the inflammatory bowel condition, a new study suggests. About one in three people with Crohn’s disease develop what’s known as a perianal fistula, which can be painful, difficult...
by Pennington Biomedical Research Center A new study offers the first evidence that a protein named BAM15 acts as an energy uncoupler and could be an effective drug for treating obesity and related diseases. Obesity affects more than 650 million people worldwide and drives a number of dangerous health conditions, including type 2 diabetes, heart...
As it stands, there are two drugs that have been approved by the Food and Drug Administration to be prescribed as PrEP, an HIV prevention strategy that when taken routinely makes it virtually impossible to contract the virus. Both of these daily drugs, Truvada and Descovy, are manufactured by Gilead. In the last couple years,...
By DONNA RACHEL EDMUNDS Changes in diet can increase the toxicity of a chemotherapeutic drug by up to 100-fold. What we eat has a direct effect on the outcome of medical treatments such as chemotherapy thanks to the interplay between our diets and the microbes in our gut, new research from the University of Virginia...
