by Baylor College of Medicine Batten disease is a family of 13 rare, genetically distinct conditions. Collectively, they are the most prevalent cause of neurodegenerative disease in children, affecting 1 in 12,500 live births in the U.S. One of the Batten disease genes is CLN6. How mutations in this gene lead to the disease has...
Researchers from Kanazawa University identify SLC35B1 as the UDP-glucuronic acid transporter into endoplasmic reticulum. This discovery suggests that SLC35B1 is a key modulator of detoxification process of drugs in the human liver. KANAZAWA UNIVERSITY Kanazawa, Japan – One of the main functions of the liver is to detoxify compounds including drugs and toxicants to reduce...
Tight regulation of calcium levels in the endoplasmic reticulum (ER) – a cellular organelle with multiple functions – contributes to insulin secretion by pancreatic beta cells. Although ER calcium handling is perturbed in diabetes, the molecular determinants of ER calcium balance are not clear. David Jacobson, Ph.D., and colleagues have now demonstrated that TALK-1 potassium...
