by Center for Genomic Regulation An organoid of human pluripotent colon cells showing MTHFD2 stained in red. Credit: Natalia Pardo Lorente/Centro de Regulación Genómica Researchers at the Center for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected “second jobs” within the nucleus, orchestrating...
Tag: <span>enzymes</span>
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What Are Digestive Enzymes?
BY AMY CAMPBELL, MS, RD, LDN, CDCES | JANUARY 3, 2023 We all need enzymes to help digest the food that we eat. Enzymes in the digestive tract help to break foods down so that the body can use the nutrients they contain. Without these enzymes, the body can become deficient in nutrients, and that...
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Beyond CRISPR: New class of gene-editing enzymes discovered
By Michael Irving September 16, 2021 MIT researchers have discovered a new class of enzymes that could open a new range of genetic engineering tools like CRISPRlightsource/Depositphotos One of the most revolutionary discoveries of the century, the CRISPR gene-editing system is built on a bacterial defense mechanism that allows scientists to make precise edits to DNA. Now...
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How a pregnant woman who smokes can be hurting her future grandchildren
by Ileana Varela, Florida International University The dangers of smoking are common knowledge. Smoking during pregnancy, even second-hand smoke, can hurt both the mother and her child. But her grandchildren? “Second-hand cigarette smoke exposure during pregnancy has damaging effects that could last for generations,” said Hitendra Chand, a biomedical researcher at the Herbert Wertheim College...
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Some ‘inert’ drug ingredients may be biologically active
by University of California, San Francisco Some supposedly inert ingredients in common drugs—such as dyes and preservatives—may potentially be biologically active and could lead to unanticipated side effects, according to a preliminary new study by researchers from the UC San Francisco School of Pharmacy and the Novartis Institutes for BioMedical Research (NIBR). Most medications include...
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Study sheds light on how cancer spreads in blood
Analysis of particles shed by tumors points to new, less invasive way to diagnose malignancies CEDARS-SINAI MEDICAL CENTER MAGNIFIED IMAGE SHOWS PROSTATE CANCER CELLS EXHIBITING FORMATION OF EXTRACELLULAR VESICLES ON THE CELL MEMBRANES, WHICH CONTAIN TUMOR-DERIVED PROTEINS AND ARE IMPLICATED IN THE SPREAD OF CANCER. view more CREDIT: IMAGE BY CEDARS-SINAI. A new study sheds...
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Solving the CNL6 mystery in Batten disease
by Baylor College of Medicine Batten disease is a family of 13 rare, genetically distinct conditions. Collectively, they are the most prevalent cause of neurodegenerative disease in children, affecting 1 in 12,500 live births in the U.S. One of the Batten disease genes is CLN6. How mutations in this gene lead to the disease has...
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The New JAK inhibitor Upadacitinib (Rinvoq) Shows Promise for Psoriatic Arthritis
Approved in 2019 for moderate to severe rheumatoid arthritis, the drug may offer an oral alternative to infused or injected biologics. The JAK inhibitor upadacitinib (Rinvoq) became a treatment option in 2019 for people with rheumatoid arthritis(RA) who had not responded well to methotrexate, the disease-modifying anti-rheumatic drug (DMARD) that is the first-line treatment for...
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Overactive enzyme causes hereditary hypertension
by Max Delbrück Center for Molecular Medicine A Turkish family from a village near the Black Sea caught the attention of medical researchers in the early 1970s, when a physician discovered that many members of this large family had both unusually short fingers and astronomically high blood pressure, sometimes twice as high as that of...
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Ground-breaking research makes childhood vaccines safe in all temperatures
Vaccines are notoriously difficult to transport to remote or dangerous places, as they spoil when not refrigerated. Formulations are safe between 2°C and 8°C, but at other temperatures the proteins start to unravel, making the vaccines ineffective. As a result, millions of children around the world miss out on life-saving inoculations. However, scientists have now...
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