by Julia Evangelou Strait, Washington University School of Medicine in St. Louis Schematic of the data generation and study design, showing the cancer types and sample types collected, the building, annotation and integration of the atlas, and the biological entities that were investigated. Credit: Nature (2023). DOI: 10.1038/s41586-023-06682-5 For decades, scientists have been sequencing the DNA...
Tag: <span>epigenome</span>
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The guardian of the (epi-)genome
UNIVERSITY OF KONSTANZ The gene coding for the protein p53 is probably the most important factor in protecting human cells from cancer caused by DNA-damaging agents. The protein allows cells to repair damage to their DNA and thereby prevents the development of cancers, which is why it has been nicknamed “the guardian of the genome”....
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Insights from our genome and epigenome will help prevent, diagnose and treat cancer
In 2020, an estimated 10 million people lost their lives to cancer. This devastating disease is underpinned by changes to our DNA – the instruction manual for all our cells. It has been 20 years since scientists first unveiled the sequence of the human genome. This momentous achievement was followed by major technological advances that...