UMEA UNIVERSITY ILLUSTRATION OF HOW THE PROTEIN SMAD7 ENHANCES THE DEVELOPMENT OF TUMORS BY REGULATING THE GENE EXPRESSION OF HDAC6 AND C-JUN. view more CREDIT: KEMAL AVICAN An increased awareness on a molecular level of what mechanisms prostate cancer cells use to become mobile and start spreading may in the long run provide new opportunities...
Conducting genetic screening in hundreds of autopsied brain samples, investigators identified shared molecular mechanisms in Alzheimer’s disease and LATE, a common brain disorder BRIGHAM AND WOMEN’S HOSPITAL Alzheimer’s disease is one of the most common causes of dementia, and while most people might know someone who is affected by it, the genetic factors behind the...
by Brian Wallheimer, Purdue University Many types of human cancers exhibit changes in kinase and phosphatase balances. Drugs that inhibit kinase activity have shown success in the clinic as cancer therapeutics, but the phosphatases still remain a largely underexploited target class due primarily to the lack of understanding of how they cause diseases. Purdue University’s...
by Terasaki Institute for Biomedical Innovation Two approaches for using biomaterials. In the more traditional approach (left), the biomaterial construct is mixed with cells and biomolecules outside of the body and then developed in an external bioreactor. The structure is then implanted into the body. In the more recently used, or “in situ” approach (right),...
Altered gene expression in fat tissue may help explain why individuals who have regained weight after weight loss surgery still experience benefits such as metabolic improvements and a reduced risk of type 2 diabetes. The findings come from a study published in the Journal of Internal Medicine. The study included women who underwent weight loss...
NEW YORK (GenomeWeb) – A team led by researchers at Washington University has identified molecular features that differ between glioblastoma (GBM) brain tumors of males and females and may be used to better tailor treatment. As they reported online yesterday in Science Translational Medicine, the researchers used available transcriptome data from the Cancer Genome Atlas...
The Xrp1 protein appears to play an important role in the development of certain forms of ALS and dementia caused by a mutation in the FUS gene. This finding of Radboud University researchers was published on September 12th in the Journal of Cell Biology. Neurons in the ‘spinal chord’ of the fruit fly. The Xrp1...
NEW YORK (GenomeWeb) – A team led by researchers at the University of Maryland and the National Cancer Institute has developed a gene expression-based predictor of response to immune checkpoint blockade therapy in metastatic melanoma patients. In a study published yesterday in Nature Medicine, the scientists, led by senior author Eytan Ruppin and first author Noam Auslander,...
