Long-lasting changes to the cells’ epigenome are linked to a decline in their function. Human fat cells (shown here in a coloured scanning electron microscopy image) carry a ‘memory’ of obesity, a study has shown.Credit: Steve Gschmeissner/SPL Even after drastic weight loss, the body’s fat cells carry the ‘memory’ of obesity, research1 shows — a finding...
Tag: <span>Fat cells</span>
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Understanding of fat cells could lead to calorie-burning treatments
Researchers hope someday to be able to tell fat cells to burn off excess calories as heat, instead of storing them and causing people to become overweight or obese. REUTERS/Finbarr O’Reilly. Understanding of fat cells could lead to calorie-burning treatments Researchers are a step closer to figuring out how to instruct fat cells to burn off excess...
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Long COVID: Could mono virus or fat cells be playing roles?
by Lindsey Tanner This photo provided by Amy Watson of Portland, Ore., shows her during an iron infusion in December 2022. Watson, approaching 50, says she has “never had any kind of recovery” from COVID-19. She has had severe migraines, plus digestive, nerve and foot problems. Recently she developed severe anemia. Credit: Amy Watson via...
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Researchers identify hormone from fat cells that restrains tumor growth in mice
UNIVERSITY OF MICHIGAN The findings offer a proof-of-concept for developing therapies against hepatocellular carcinoma, the most common form of liver cancer. Jiandie Lin and his team use mice as a model to study how molecular and cellular changes are affected by nonalcoholic fatty liver disease, and how these changes consequently lead to the progression of this...
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Pimple secret popped: How fat cells in the skin help fight acne
by University of California – San Diego Microscopic image of an inflamed pimple with cathelicidin stained red, fat cells stained green and the nuclei of every cell stained blue. Because cathelicidin is produced from fat cells, their staining merges together. Credit: UC San Diego Health Sciences Acne is among the most common skin diseases in...
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‘Energy crisis’ in fat cells behind inflammation associated with obesity
by Karolinska Institutet Fig. 1: Obesity is associated with altered phosphocreatine/creatine metabolism in human WAT. a, Polar metabolites in subcutaneous WAT of obese (n = 13) and non-obese (NO, n = 13) subjects (cohort 1) highlighting metabolites in the phosphocreatine/creatine pathway (green dots). Data are represented in a volcano plot with fold changes (log2) and adjusted P values (negative...
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Breakthrough in using CRISPR-Cas9 to target fat cells
Fat—it is vital for life but too much can lead to a host of health problems. Studying how fat, or adipose, tissue functions in the body is critical for understanding obesity and other issues, yet structural differences in fat cells and their distribution throughout the body make doing so challenging. “Fat cells are different from...
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Gene editing can turn storage fat cells into energy-burning fat cells
by UT Southwestern Medical Center Lavanya Vishvanath, Senior Research Associate and Rana Gupta, Ph.D. in the research lab. Credit: UT Southwestern Medical Center A team of researchers at UT Southwestern Medical Center’s Touchstone Diabetes Center have successfully used CRISPR gene editing to turn fat cells normally used for storage into energy-burning cells. “It’s like flipping a switch. We removed the ‘brake’ on...
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COVID-19 may trigger hyperglycemia and worsen disease by harming fat cells
by Weill Cornell Medical College Credit: Pixabay/CC0 Public Domain COVID-19 may bring high risks of severe disease and death in many patients by disrupting key metabolic signals and thereby triggering hyperglycemia, according to a new study from researchers at Weill Cornell Medicine and NewYork-Presbyterian. In the study, reported Sept. 15 in Cell Metabolism, the researchers found that hyperglycemia—having high blood sugar levels—is common in hospitalized COVID-19 patients and is strongly associated with worse outcomes. The researchers also found evidence suggesting that SARS-CoV-2,...
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Signals from fat, not excess loading, lead to painful joint disease
SHRINERS HOSPITALS FOR CHILDREN IMAGE: LEAD AUTHOR OF THE STUDY, DR. KELSEY COLLINS IS A POSTDOCTORAL FELLOW IN GUILAK’S LABORATORY. CREDIT: SHRINERS HOSPITALS FOR CHILDREN (St. Louis) – A new study by investigators at the Shriners Hospital for Children — St. Louis suggests the damaging effects of obesity are not due to body weight but...
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