The largest analysis to date of genetic data in amyotrophic lateral sclerosis (ALS) – the muscle-crippling neurodegenerative disease that afflicted the late astrophysicist Stephen Hawking and cut short the career of iconic Yankee baseball slugger Lou Gehrig – has identified two previously unrecognized genetic risks that are significantly associated with the disease. In the...
Tag: <span>frontotemporal dementia (FTD)</span>
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New insight into how brain cells die in Alzheimer’s and FTD
Epigenetic regulator LSD1 tangled up; brain cells go haywire without it Removal of a regulatory gene called LSD1 in adult mice induces changes in gene activity that look unexpectedly like Alzheimer’s disease, scientists have discovered. Researchers also discovered that LSD1 protein is perturbed in brain samples from humans with Alzheimer’s disease and frontotemporal dementia (FTD)....