by Krishna Ramanujan, Cornell University Associative and predictive codes in the hippocampus. Our optogenetic manipulation perturbed hippocampal sequences without affecting cell coactivity, thus selectively disrupting the predictive code. After learning, cell assemblies were reactivated, but their order was not preserved, abolishing sequential replay (right). Perturbing the predictive code had no effect on associative learning (bottom left)...
