October 2, 2024 by University of Chicago Inside every cell, inside every nucleus, your continued existence depends on an incredibly complicated dance. Proteins are constantly wrapping and unwrapping DNA, and even minor missteps can lead to cancer. A new study from the University of Chicago reveals a previously unknown part of this dance—one with significant...
Tag: <span>gene expression</span>
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Researchers pioneer noninvasive measurement of gene expression at target locations in the brain
August 7, 2024 by Silvia Cernea Clark, Rice University Striatum region (left) in rodent brain with opened blood-brain barrier. Green fluorescent protein expressed in striatum region in rodent brain (right) in response to induced neuronal activity. Credit: Laboratory for Noninvasive Imaging/Rice UniversityThe ability to alter or prevent the expression of faulty genes in the brain...
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Scientists use blood test to track gene expression in the brain
by Kayt Sukel, Rice University Scan of mouse hippocampus and cortex, where the red signal derives from immunostaining for the synthetic marker developed by the Szablowski lab and the blue from the immunostaining of c-Fos, an endogenous protein whose production is heightened by increased neuronal activity. Credit: Szablowski lab/Rice UniversityThe brain is the most protected organ...
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AI combined with CRISPR precisely controls gene expression
by New York University Credit: Unsplash/CC0 Public Domain Artificial intelligence can predict on- and off-target activity of CRISPR tools that target RNA instead of DNA, according to new research published in Nature Biotechnology. The study by researchers at New York University, Columbia University, and the New York Genome Center, combines a deep learning model with CRISPR screens to control...
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Researchers identify gene expression signature that predicts progression of type 1 diabetes
by University of Turku Correlations of gene expression ratios between the baseline and 1-year follow-up samples (i.e., expression change) against zinc transporter 8 (ZnT8) autoantibody status at baseline. (a) Uniform manifold approximation and projection dimensional reduction of all gene ratios (n = 46), colored on the basis of the correlation. (b) Examples of gene ratios between the baseline...
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Gender and age differences found in gene expression related to circadian clock
by Bob Yirka, Medical Xpress Genome-wide rhythmicity analysis and TF regulation. (A) Number of rhythmic genes (q(BH) < 0.2 and log2 peak-trough > 0.5) with q-value smaller than a threshold (x-axis) plotted as a function of the threshold across 46 tissues. (B) Number of common rhythmic genes (q(BH) < 0.2 and log2 peak-trough > 0.5)...
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Time-restricted eating reshapes gene expression throughout the body
SALK INSTITUTE IMAGE: TIME-RESTRICTED EATING RESHAPES GENE EXPRESSION THROUGHOUT THE BODY. IN THIS ILLUSTRATION, THE FERRIS WHEEL DISPLAYS THE INTERCONNECTED ORGAN SYSTEMS WORKING SMOOTHLY DURING TIME-RESTRICTED EATING, WHICH IS REPRESENTED BY THE CLOCK IN THE MIDDLE. CREDIT: SALK INSTITUTE LA JOLLA (January 3, 2023)— Numerous studies have shown health benefits of time-restricted eating including increase...
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New imaging technique allows researchers to see gene expression in brains of live mice in real time
by University of Minnesota A University of Minnesota Twin Cities-led team has developed a new technique for imaging mRNA molecules in the brains of living mice. By genetically modifying a mouse so that it produced mRNA labeled with green fluorescent proteins (shown above), the researchers were able to see when and where the mouse’s brain...
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Recently Discovered Protein Turbocharges Gene Expression
An ancient protein found in all human tissues enhances gene activation and may be involved in diseases such as cancer. For many years, scientists have sought to understand what happens when our genes are flipped to the “on” position. Now, scientists at the University of California San Diego and Rutgers University have identified a new...
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Gene expression profile allows identification of anti-tumor immune cells for personalized immunotherapy
by National Institutes of Health Workflow for prospective identification of anti-tumor, neoantigen-specific TCRs using NeoTCR signature. Based on single cell gene signature scoring of TIL clusters, we first identify candidate NeoTCR4 and NeoTCR8 cluster populations. Dominant and subdominant clonotypes within the the two candidate NeoTCR clusters are reconstructed and tested against autologous patient tumor mutations,...
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