by Kayt Sukel, Rice University Scan of mouse hippocampus and cortex, where the red signal derives from immunostaining for the synthetic marker developed by the Szablowski lab and the blue from the immunostaining of c-Fos, an endogenous protein whose production is heightened by increased neuronal activity. Credit: Szablowski lab/Rice UniversityThe brain is the most protected organ...
by New York University Credit: Unsplash/CC0 Public Domain Artificial intelligence can predict on- and off-target activity of CRISPR tools that target RNA instead of DNA, according to new research published in Nature Biotechnology. The study by researchers at New York University, Columbia University, and the New York Genome Center, combines a deep learning model with CRISPR screens to control...
by University of Turku Correlations of gene expression ratios between the baseline and 1-year follow-up samples (i.e., expression change) against zinc transporter 8 (ZnT8) autoantibody status at baseline. (a) Uniform manifold approximation and projection dimensional reduction of all gene ratios (n = 46), colored on the basis of the correlation. (b) Examples of gene ratios between the baseline...
by Bob Yirka, Medical Xpress Genome-wide rhythmicity analysis and TF regulation. (A) Number of rhythmic genes (q(BH) < 0.2 and log2 peak-trough > 0.5) with q-value smaller than a threshold (x-axis) plotted as a function of the threshold across 46 tissues. (B) Number of common rhythmic genes (q(BH) < 0.2 and log2 peak-trough > 0.5)...
SALK INSTITUTE IMAGE: TIME-RESTRICTED EATING RESHAPES GENE EXPRESSION THROUGHOUT THE BODY. IN THIS ILLUSTRATION, THE FERRIS WHEEL DISPLAYS THE INTERCONNECTED ORGAN SYSTEMS WORKING SMOOTHLY DURING TIME-RESTRICTED EATING, WHICH IS REPRESENTED BY THE CLOCK IN THE MIDDLE. CREDIT: SALK INSTITUTE LA JOLLA (January 3, 2023)— Numerous studies have shown health benefits of time-restricted eating including increase...
by University of Minnesota A University of Minnesota Twin Cities-led team has developed a new technique for imaging mRNA molecules in the brains of living mice. By genetically modifying a mouse so that it produced mRNA labeled with green fluorescent proteins (shown above), the researchers were able to see when and where the mouse’s brain...
An ancient protein found in all human tissues enhances gene activation and may be involved in diseases such as cancer. For many years, scientists have sought to understand what happens when our genes are flipped to the “on” position. Now, scientists at the University of California San Diego and Rutgers University have identified a new...
by National Institutes of Health Workflow for prospective identification of anti-tumor, neoantigen-specific TCRs using NeoTCR signature. Based on single cell gene signature scoring of TIL clusters, we first identify candidate NeoTCR4 and NeoTCR8 cluster populations. Dominant and subdominant clonotypes within the the two candidate NeoTCR clusters are reconstructed and tested against autologous patient tumor mutations,...
by Michaela Kane, Duke University Podocyte Models. Credit: Duke University Biomedical engineers at Duke University have developed a method to study how key cells in the kidneys become injured and deformed. The new model has revealed a significant mechanism behind severe kidney disease and pointed toward early disease biomarkers and potential therapeutic interventions. The study...
by The Francis Crick Institute Genes from a reduced published signature of TB risk are increasingly differentially expressed in incipient, subclinical, and clinical TB patients. (A) List of published TB 16-gene risk signature from Zak et al. (2016) where *** indicates the presence of a 30-gene signature from Leicester incipient, subclinical TB, and clinical TB from...
