Jim Kling December 17, 2024 139 For gout, xanthine oxidase (XO) inhibitors are the choice for first-line urate-lowering therapy (ULT) according to the 2020 American College of Rheumatology Guideline for the Management of Gout, which endorsed allopurinol, but should that be the approach for all patients, or should first-line therapy be tailored to the mechanism of...
Tag: <span>Gout</span>
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Obesity Reduces Response to Urate-Lowering Therapy in Men With Gout
Edited by Shreyasi Asthana February 20, 2025 015 TOPLINE: Obesity significantly reduced the effectiveness of febuxostat-based urate-lowering therapy among men with gout, with those with obesity showing lower target achievement rates and more flares than their normal-weight counterparts. METHODOLOGY: TAKEAWAY: IN PRACTICE: “Personalized medication is necessary for obese male patients to prevent gout flares and...
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Plant-Based Diet Improves Uric Acid Levels, Gout Symptoms
Jim Kling November 25, 2024 2532 A Mediterranean-inspired plant-based diet improved self-reported measures of gout as well as uric acid levels, a pilot study has found. There hasn’t been a lot of research on diet in gout, according to Anna Kretova, RD, who presented the study at the annual research symposium of the Gout Hyperuricemia and...
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Plant-Based Diet Improves Uric Acid Levels, Gout Symptoms
Jim Kling November 25, 2024 1208 Added to Email Alert A Mediterranean-inspired plant-based diet improved self-reported measures of gout as well as uric acid levels, a pilot study has found. There hasn’t been a lot of research on diet in gout, according to Anna Kretova, RD, who presented the study at the annual research symposium...
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Study finds genetics, not lifestyle, is a major cause of gout
Linking of insulin signaling, the tricarboxylic acid cycle and epigenomic reprogramming cellular pathways with candidate gout-associated genes. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01921-5 A major international study has found that gout is a chronic illness in which genetics is a major cause, rather than the lifestyle choices of the sufferer. Led by University of Otago researchers, the genome-wide...
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Urate transporter structures reveal the mechanism behind important drug target for gout
September 9, 2024 by St. Jude Children’s Research Hospital Cryo-EM structures of human URAT1 in different functional states. Credit: Cell Research (2024). DOI: 10.1038/s41422-024-01023-1Scientists at St. Jude Children’s Research Hospital have used cryo-electron microscopy to generate ten structures of URAT1, a protein linked to gout. Gout is a type of arthritis caused by excess urate...
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Study finds risk for benign prostatic hyperplasia increases for patients with gout
by Elana Gotkine Patients with gout, especially those younger than 60 years, have an increased risk for benign prostatic hyperplasia (BPH), according to a study published online Dec. 26 in Diagnostics. Woo Jin Bang, from the Hallym University College of Medicine in Anyang, South Korea, and colleagues retrieved data from 514,866 Korean National Health Insurance...
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Gout strongly associated with reduced gray matter and increased neurodegenerative disease
by Justin Jackson, Medical Xpress Differences in regional gray matter volume between participants with gout (n = 1,165) and controls (n = 32,202), as analyzed by voxel-based morphometry. Blue regions represent areas where participants with gout had significantly less gray matter. T statistics are thresholded at a 5% false discovery rate (0.0013 threshold on uncorrected P values). Models adjusted...
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Gout unveiled as surprising culprit in neurodegenerative diseases
By Bhavana Kunkalikar May 22 2023 Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Nature Communications, researchers explore the relationship between gout and neurodegenerative disease susceptibility. Study: Association of gout with brain reserve and vulnerability to neurodegenerative disease. Image Credit: Triff / Shutterstock.com What is gout? Gout, which is often referred to as hyperuricemia, is...
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Gout: How metabolic syndrome may increase the risk
Researchers say people with metabolic syndrome have a higher risk of gout. Eddie Pearson/Stocksy Metabolic syndrome (MetS) appears to increase the likelihood of several conditions occurring together, such as cardiovascular disease, high cholesterol, obesity, and type 2 diabetes. The syndrome is not a singular, distinct disease, but rather a collection of risk factors that have been...