Linking of insulin signaling, the tricarboxylic acid cycle and epigenomic reprogramming cellular pathways with candidate gout-associated genes. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01921-5 A major international study has found that gout is a chronic illness in which genetics is a major cause, rather than the lifestyle choices of the sufferer. Led by University of Otago researchers, the genome-wide...
Tag: <span>Gout</span>
Post
Urate transporter structures reveal the mechanism behind important drug target for gout
September 9, 2024 by St. Jude Children’s Research Hospital Cryo-EM structures of human URAT1 in different functional states. Credit: Cell Research (2024). DOI: 10.1038/s41422-024-01023-1Scientists at St. Jude Children’s Research Hospital have used cryo-electron microscopy to generate ten structures of URAT1, a protein linked to gout. Gout is a type of arthritis caused by excess urate...
Post
Study finds risk for benign prostatic hyperplasia increases for patients with gout
by Elana Gotkine Patients with gout, especially those younger than 60 years, have an increased risk for benign prostatic hyperplasia (BPH), according to a study published online Dec. 26 in Diagnostics. Woo Jin Bang, from the Hallym University College of Medicine in Anyang, South Korea, and colleagues retrieved data from 514,866 Korean National Health Insurance...
Post
Gout strongly associated with reduced gray matter and increased neurodegenerative disease
by Justin Jackson, Medical Xpress Differences in regional gray matter volume between participants with gout (n = 1,165) and controls (n = 32,202), as analyzed by voxel-based morphometry. Blue regions represent areas where participants with gout had significantly less gray matter. T statistics are thresholded at a 5% false discovery rate (0.0013 threshold on uncorrected P values). Models adjusted...
Post
Gout unveiled as surprising culprit in neurodegenerative diseases
By Bhavana Kunkalikar May 22 2023 Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Nature Communications, researchers explore the relationship between gout and neurodegenerative disease susceptibility. Study: Association of gout with brain reserve and vulnerability to neurodegenerative disease. Image Credit: Triff / Shutterstock.com What is gout? Gout, which is often referred to as hyperuricemia, is...
Post
Gout: How metabolic syndrome may increase the risk
Researchers say people with metabolic syndrome have a higher risk of gout. Eddie Pearson/Stocksy Metabolic syndrome (MetS) appears to increase the likelihood of several conditions occurring together, such as cardiovascular disease, high cholesterol, obesity, and type 2 diabetes. The syndrome is not a singular, distinct disease, but rather a collection of risk factors that have been...
Post
Gout: Combining 2 existing drugs doubles treatment success in new study
Gout is a form of arthritis that results from excess uric acid in the bloodstream and causes intense pain, swelling, and stiffness around a joint. Doctors often treat severe gout with pegloticase (Krystexxa), a medication that reduces uric acid levels, but the body’s immune response to the drug limits its effects. By combining Krystexxa with...
Post
History of gout tied to risk for BPPV, Meniere disease
by Elana Gotkine A history of gout is associated with an increased risk for benign paroxysmal positional vertigo (BPPV) and Meniere disease, according to a study published online Dec. 26 in the Journal of Clinical Medicine. Hyo Geun Choi, M.D., from the Hallym University College of Medicine in Seoul, South Korea, and colleagues examined the impact of preexisting gout on...
Post
New look at an ancient disease: Study finds novel treatment targets for gout
UNIVERSITY OF CALIFORNIA – SAN DIEGO IMAGE: JAMES GILLRAY’S 1799 PAINTING ILLUSTRATES THE PAINFUL SYMPTOMS OF GOUT. CREDIT: WELLCOME LIBRARY, LONDON / HTTPS://CREATIVECOMMONS.ORG/LICENSES/BY/4.0/ Many Americans think of gout as a disease from a bygone era, akin to rickets or scurvy. The condition commonly afflicted the rich and royal, including American historical figures such as Benjamin Franklin...
Post
Is metabolic syndrome a modifiable risk factor for gout?
by Wiley Credit: Pixabay/CC0 Public Domain In a study published in Arthritis & Rheumatology that included nearly 1.3 million men aged 20–39 years who participated in three serial health check-ups at two-year intervals, men with metabolic syndrome (MetS) and those who developed MetS—especially those with the MetS components of elevated triglycerides and abdominal obesity—had higher risks of...