by American Society for Microbiology Credit: CC0 Public DomainSevere gum disease has been linked to the progression of chronic obstructive pulmonary disease, or COPD, but an understanding of how the connection plays out in the immune system remains unclear. This week in mSystems, a new study identifies immune system cells that play a critical role in...
by Laurie Kaiser, University at Buffalo Credit: George Becker from Pexels Individuals with type 2 diabetes being treated for periodontitis may benefit from using an antimicrobial mouth rinse and small brushes to clean between teeth as part of their at-home oral care routine. This was a key finding in a recent study conducted by Patricia Diaz,...
by Forsyth Institute Alveolar bone resorption and mRNA expression levels of RANKL and OPG in periodontal tissues of mice with ligature-induced experimental periodontal disease. A) In vivo experimental design (n = 36, 7–8 mice per group). The baseline group was left untreated, and four groups had ligatures around maxillary right and left second molars for different timepoints corresponding...
by Rockefeller University Blood vessels in the soft tissue between joints, during a rheumatoid arthritis flare-up. Credit: Laboratory of Molecular Neuro-oncology at The Rockefeller University It’s a well-documented medical mystery: Patients with gum disease are less likely to respond to rheumatoid arthritis treatments. But new research may help explain this link between gum disease and an otherwise disparate...
by Justin Jackson, Medical Xpress Oral mucosal breaks trigger systemic inflammatory responses.(A) Experimental workflow. (B) Inferred relative bacterial abundances from eight HMP body sites (n = 336). (C) Body site–inferred relative abundances for time points from RA patients with and without periodontal disease, median. (D) Inferred relative oral abundances in blood for one RA donor with and...
by University of Birmingham Change in area under the curve (AUC) for all combinations of validated analytes for differentiating between health or gingivitis and periodontitis (HG vs. P), health and gingivitis (H vs. G), and mild and advanced periodontitis (MP vs. AP). Data are represented as truncated violin plots; solid lines represent median and dashed...
A new gel may be able to relieve and treat symptoms of gum disease. Anna Efetova/Getty Images Almost half of all adults ages 30 or older have gum disease. Researchers from the NYU College of Dentistry have developed a topical gel to help treat and prevent periodontal (gum) disease. In experiments in mice, the gel...
by New York University A topical gel that blocks the receptor for a metabolic byproduct called succinate treats gum disease by suppressing inflammation and changing the makeup of bacteria in the mouth. Credit: Yuqi Guo A topical gel that blocks the receptor for a metabolic byproduct called succinate treats gum disease by suppressing inflammation and...
The bacteria, fusobacterium nucleatum (F. nucleatum), proliferates in periodontal disease and affects the gums and jawbone. If untreated, it results in unstable teeth and tooth loss. In recent years, studies have linked F. nucleatum to conditions ranging from colorectal cancer to premature delivery of babies. “In this study, our lab is the first to find that Fusobacterium nucleatum can generate systemic inflammation and...
TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY IMAGE: TLR3 SIGNALING ACTIVATED BY DS RNA [POLY(I:C)] ANALOGUE INDUCES THE PGE2-MEDIATED EXPRESSION OF RANKL THAT STIMULATES OSTEOCLAST FORMATION AND DIRECTLY PROLONGS THE LIFE SPAN OF MATURE OSTEOCLASTS, THAT WAS LEADING ALVEOLAR BONE RESORPTION IN PERIODONTAL DISEASE. CREDIT: MASAKI INADA, TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY Tokyo University of...
