by Columbia University Irving Medical Center Graphical abstract. Credit: Immunity (2023). DOI: 10.1016/j.immuni.2023.11.003The microbiome has a profound influence on our health, but exactly how our resident bacteria wield their power is still unclear. A type of T cell appears to provide some answers for gastrointestinal health, a study of the mouse microbiome finds. The study, appearing...
Sarah Amandolare August 02, 2023 A popular ingredient in the American diet has been linked to ulcerative colitis. The ingredient is soybean oil, which is very common in processed foods. In fact, U.S. per capita consumption of soybean oil increased more than 1,000-fold during the 20th century. In a study from the University of California Riverside and UC Davis,...
by Allessandra DiCorato, Broad Institute of MIT and Harvard Graphical abstract. Credit: Immunity (2023). DOI: 10.1016/j.immuni.2023.01.002 Researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital have constructed a high-resolution cellular map of Crohn’s disease, a chronic condition in which a hyperactive immune system causes inflammation throughout the gut, leading to symptoms including abdominal...
by Salk Institute Salk researchers discovered the compound FexD can treat intestinal inflammation in mice. Mice with symptoms similar to inflammatory bowel disease had changes to the cells lining their intestines (left) that were reversed with treatment (right). Credit: Salk Institute A drug developed by Salk Institute researchers acts like a master reset switch in...
by Van Andel Research Institute Chronic inflammation in the gut may propel processes in the body that give rise to Parkinson’s disease, according to a study by scientists at Van Andel Institute and Roche. The study, published in Free Neuropathology, is the latest in a growing list that links the gut and the immune system to Parkinson’s. The researchers’ findings in an...
Eating a Western diet impairs the immune system in the gut in ways that could increase the risk of infection and inflammatory bowel disease, according to a study from researchers at Washington University School of Medicine in St. Louis and Cleveland Clinic. The study, in mice and people, showed that a diet high in sugar...
New detail about what happens when a key cellular process is impaired in cells that are vital for a healthy gut have been uncovered by a wide-ranging analysis. Paneth cells are found at the bottom of crypts in the lining of the gut. They help defend against pathogenic microbes, as well as protecting the integrity...
