by Quadram Institute Interactions of 48 BEV proteins with monocytes, macrophages and dendritic cells in healthy (a) and UC (b) conditions. Number of expressed genes/number of interacting proteins are highlighted for each cell-type. Credit: Journal of Extracellular Vesicles (2022). DOI: 10.1002/jev2.12189 Around 500,000 people in the UK live with Inflammatory Bowel Disease (IBD), a life-long, chronic condition...
Miodrag Ignjatovic/Getty Images Long COVID is a condition that involves persistent symptoms for weeks or months after initial infection with SARS-CoV-2, the coronavirus that causes COVID-19. People with a less diverse microbiome in their intestines were more likely to have lingering symptoms after coronavirus infection. The exact cause of long COVID — and why some...
by Quadram Institute Fig 1. In silico analysis of RgGH98. (A) SSN analysis of GH98 family. Amino acid sequences were from the CAZy database (www.cazy.org). A total of 355 GH98 sequences were analyzed by SSN with an alignment score of 120. Each node (blue dot) represents one protein sequence. The functionally characterized enzymes are color...
In today’s open access paper, the authors report on their investigation of the effects of nicotinamide mononucleotide (NMN) supplementation on the gut microbiome in mice. The gut microbiome changes with age, exhibiting a loss of helpful populations that produce metabolites necessary to health, and the growth in harmful populations that provoke chronic inflammation. Rejuvenating the aged gut microbiome via fecal microbiota transplantation from a...
by CUNY Advanced Science Research Center A new study has identified gut-derived metabolites that appear to be neurotoxic and play a role in the progression of multiple sclerosis. Credit: Nicoletta Barolini A New York-based, multi-institutional research team has found high levels of three toxic metabolites produced by gut bacteria in the cerebrospinal fluid and plasma samples...
by Mike McNulty, University of Southern California Figure modified from Mayer [9] depicting diversity and abundance of gut microbes across the lifespan of a human. Early and late periods of low diversity coincide with vulnerability to neurodevelopmental disorders and neurodegenerative disorders, respectively. IBS = Irritable Bowel Syndrome. Credit: DOI: 10.3390/nu13124497 A new scoping review of...
by University of Pittsburgh Tertiary lymphoid structures, which contain Helper T cells, B cells, and natural killer cells, create a favorable environment for immune cell maturation and indicate cancer treatments are more likely to be successful. Credit: Abigail Overacre-Delgoffe A bacterium common in the mouse gut microbiome can charge up the immune system to fight...
By Rich Haridy November 30, 2021 New research looked at how a common food additive used as an emulsifier influences the gut microbiome NewAfrica/Depositphotos A first-of-its-kind study investigating the effects of a common food additive on human gut bacteria has found the emulsifier carboxymethylcellulose can alter the quality and composition of the microbiome and potentially...
By Michael Irving November 28, 2021 Bacteriophages attack a bacterium, which according to a new study could be useful for manipulating the gut microbiomeiLexx/Depositphotos Scientists at the University of California San Francisco (UCSF) have successfully edited the genome of bacteria in the gut microbiome of living mice, for the first time. Bacteria-hunting viruses are loaded...
Fresno, CA – A new clinical study published in the scientific journal Nutrients found that consuming grapes significantly increased the diversity of bacteria in the gut which is considered essential to good health overall. Additionally, consuming grapes significantly decreased cholesterol levels, as well as bile acids which play an integral role in cholesterol metabolism. The findings suggest...
