by National Institutes of Health Localization of α-syn Ser129P and effects of phosphorylation on synaptic targeting. Credit: Neuron (2023). DOI: 10.1016/j.neuron.2023.11.020Researchers have discovered that a protein called phosphorylated α-synuclein, which is associated with several neurodegenerative diseases such as Parkinson’s disease and Lewy body dementia, is also involved in the normal processes of how neurons communicate with...
by Stefanie Tremblay, The Conversation Modifiable risk factors for dementia include high blood pressure, obesity, physical inactivity, diabetes, smoking, excessive alcohol consumption and infrequent social contact. Credit: ShutterstockA 65-year-old woman repeatedly seeks medical help for her failing memory. She is first told it’s nothing to worry about, then, a year later, that it’s “just normal...
UNIVERSITY OF HEIDELBERG IMAGE: LACK OF THE APP FAMILY LEADS TO ABNORMAL POSITIONING OF NEURONS (YELLOW) IN THE HIPPOCAMPUS. NEURONS LACKING APP FAMILY PROTEINS SHOW FEWER SYNAPTIC CONNECTIONS. CREDIT: SUSANNE KLEIN, PROF. MÜLLER’S RESEARCH GROUP, HEIDELBERG UNIVERSITY While the APP protein is well-known for its key role in Alzheimer’s disease, its contribution to healthy brain...
by Virginia Tech Michael Fox, a professor at the Fralin Biomedical Research Institute at VTC and director of the School of Neuroscience in Virginia Tech’s College of Science, led a study that may help reveal the molecular underpinnings of seizures and psychiatric disorders. Credit: Virginia Tech A research team led by Michael Fox, a professor at...
