by Anna Jones, University of Alabama at Birmingham Credit: Unsplash/CC0 Public Domain A new study published in the Journal of the American Medical Association led by researchers from the University of Alabama at Birmingham Marnix E. Heersink School of Medicine found that being a carrier of a genetic variation known as Val122Ile in the transthyretin, or TTR...
by American College of Physicians Credit: Unsplash/CC0 Public Domain A systematic review and meta-analysis of randomized control trials (RCTs) found that sodium-glucose cotransporter-2 (SGLT2) inhibitors reduce hospitalizations and may reduce cardiovascular deaths among people experiencing heart failure regardless of the presence of diabetes. These findings support existing guidelines that recommend SGLT2 inhibitors for preventing incident...
by University of Alberta Credit: Pixabay/CC0 Public Domain For the past century people with weak hearts have been told to lower their salt intake, but until now there has been little scientific evidence behind the recommendation. The largest randomized clinical trial to look at sodium reduction and heart failure reported results simultaneously in The Lancet and at the American College...
by American College of Cardiology Credit: Unsplash/CC0 Public Domain Patients with heart failure with reduced ejection fraction (HFrEF) did not experience any improvement in their ability to exercise vigorously after taking the experimental heart failure drug omecamtiv mecarbil, in a study presented at the American College of Cardiology’s 71st Annual Scientific Session. Many patients who...
Approval for Jardiance (empagliflozin) has been expanded to reduce the risk for cardiovascular death and hospitalization for heart failure in adults, the U.S. Food and Drug Administration announced Thursday. Jardiance previously received approval in 2014 as a supplement to diet and exercise for improving glucose control in adults with type 2 diabetes. The drug is...
By Nick Lavars February 08, 2022 A new kind of pacemaker could change the way heart failure is treated, by adjusting heartbeats in response to breathing Depositphotos While modern pacemakers have proven an invaluable and lifesaving medical tool, the way they regulate the pace of the heart differs from the varying beat of the organ...
by Wiley Credit: Pixabay/CC0 Public Domain A review published in the Journal of Internal Medicine provides convincing evidence that micronutrients—including iron, selenium, zinc, copper, and coenzyme Q10—can impact the function of cardiac cells’ energy-producing mitochondria to contribute to heart failure. The findings suggest that micronutrient supplementation could represent an effective treatment for heart failure. “Micronutrient deficiency has...
by Fraunhofer-Gesellschaft To better understand the molecular signaling pathways in healthy and diseased hearts, researchers are analyzing non-coding miRNA using real-time PCR. This can be used to identify disease-related miRNAs, such as miRNA 132. Credit: Fraunhofer-Gesellschaft RNA has already been making an impact in the context of the vaccine program, but the potential of RNA-based...
by Baylor College of Medicine Credit: Unsplash/CC0 Public Domain Disrupting circadian rhythms, which change naturally on a 24-hour cycle, has been implicated in heart disease, but it is unclear how it leads to the condition. A research team at Baylor College of Medicine and collaborating institutions investigated the function of the protein Rev-erbα/β, a key...
by Ana María Rodríguez, Ph.D., Baylor College of Medicine Using endothelial cell plasticity to improve fibroblast reprograming efficiency. Credit: The authors / Scott Holmes, C.M.I. Not too long ago, the idea of taking—for instance—a skin cell and transforming it into a muscle cell was unthinkable. About 10 years ago, however, revolutionary research showed that it...
