by Melissa Rohman, Northwestern University Effects of dapagliflozin on selected secondary endpoints and in supportive responder analysis. a–c, Effects of dapagliflozin on selected secondary endpoints and in supportive responder analysis. Effects of dapagliflozin versus placebo at 12 weeks on 6MWT distance (a), KCCQ-CS responder analysis (b) and KCCQ-OS (c). Data are presented as mean values with 95%...
(© blueskies9 – stock.adobe.com)HEART HEALTH by Chris Melore SOPHIA ANTIPOLIS, France — Aspirin is one of the most common pain relievers in the world, but a new study finds it may be contributing to heart failure. Researchers with the European Society of Cardiology find taking aspirin raises the risk of heart failure among people with at least...
by American Heart Association Credit: Unsplash/CC0 Public Domain Canagliflozin, a medication used to treat type 2 diabetes, was found to greatly improve symptoms and quality of life within 3 months for people with heart failure due to either reduced or preserved cardiac function, even if they didn’t also have type 2 diabetes, according to late-breaking...
A new study led by researchers at Washington University School of Medicine in St. Louis suggests that a widely used heart failure drug named sacubitril/valsartan is no better than valsartan alone in patients with severe heart failure. The study also provides evidence that the treatment with valsartan may be slightly safer for patients with advanced...
MINNEAPOLIS/ST. PAUL (10/19/2021) – Recent studies may point towards a new therapeutic mechanism for a type of heart failure that currently has no specific treatment option. Researchers from the University of Minnesota Medical School — along with the University of Vermont and the Medical University of South Carolina — looked into a condition called heart failure with...
by The Mount Sinai Hospital Researchers at Icahn School of Medicine at Mount Sinai developed an electrocardiogram-reading algorithm that can detect subtle signs of heart failure. Credit: Glicksberg and Nadkarni labs, Mount Sinai, N.Y., N.Y. A special artificial intelligence (AI)-based computer algorithm created by Mount Sinai researchers was able to learn how to identify subtle changes...
This paper is interesting as a first step on the way to further research into compensatory therapies that can reduce the cardiac muscle dysfunction of heart failure. One-time radiation therapyappears to persistently change cardiomyocyte behavior via altered epigenetic regulation of notch signaling, leading to modestly improved heart tissue function. Perhaps this should be taken as supportive of efforts to more directly target this regulatory pathway in...
by University of Birmingham Credit: Unsplash/CC0 Public Domain Researchers at the University of Birmingham have developed a new way to identify patients with heart failure who will benefit from treatment with beta-blockers. Their study involved 15,669 patients with heart failure and reduced left ventricular ejection fraction (low function of the heart’s main pumping chamber), 12,823 of which were in normal heart rhythm...
by European Society of Cardiology Credit: Pixabay/CC0 Public Domain Staying well hydrated throughout life could reduce the risk of developing heart failure, according to research presented at ESC Congress 2021. “Our study suggests that maintaining good hydration can prevent or at least slow down the changes within the heart that lead to heart failure,” said study author Dr. Natalia...
by American Heart Association Credit: Unsplash/CC0 Public Domain Sarpogrelate, an antiplatelet medication, has potential as a new heart failure therapy and, according to researchers, could potentially decrease health care costs associated with cardiovascular disease, according to preliminary animal research presented at the American Heart Association’s Basic Cardiovascular Sciences Scientific Sessions 2021. Cardiac hypertrophy is the abnormal enlargement, or thickening, of...
