Immunotherapy could be used to enhance immune responses in older people, making them less vulnerable to infections. News Published: May 16, 2024 | Original story from the University of Minnesota Credit: Congerdesign/ Pixabay Published in Nature Aging, University of Minnesota Medical School researchers provided new insight into enhancing immune responses in older individuals and the...
by Gabriele Meseg-Rutzen, University of Cologne Keeping the immune system in checkModel of RHBDL4-mediated negative feedback regulation of TLR4 signaling. RHBDL4-catalyzed cleavage induces downregulation of TMED7 by the ERAD pathway. Upon loss of RHBDL4, TMED7 accumulates and promotes the trafficking of TLR4 to the cell surface. Consequently, TLR4 downstream signaling is increased, resulting in enhanced...
by Gabriele Meseg-Rutzen, University of Cologne Model of RHBDL4-mediated negative feedback regulation of TLR4 signaling. RHBDL4-catalyzed cleavage induces downregulation of TMED7 by the ERAD pathway. Upon loss of RHBDL4, TMED7 accumulates and promotes the trafficking of TLR4 to the cell surface. Consequently, TLR4 downstream signaling is increased, resulting in enhanced cytokine secretion. As negative feedback, LPS-induced...
Researchers are reporting that some early-stage cancer cells activate a gene that helps hide them from the body’s immune response.They say that identifying this uptick in gene expression among cancer cells could lead to new pathways for early diagnosis and future treatment of colon cancer.Experts say more research is needed, however, to confirm these findings...
A new study finds precancerous colon cells turn on a gene called SOX17, which helps them evade detection and develop into more advanced tumors.Peer-Reviewed Publication MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA — One of the immune system’s primary roles is to detect and kill cells that have acquired cancerous mutations. However, some early-stage cancer cells...
by Cold Spring Harbor Laboratory Graphical abstract. Credit: Molecular Cell (2024). DOI: 10.1016/j.molcel.2024.01.007Our immune system is remarkably powerful. It quickly assembles teams of cells to eliminate threats inside our bodies. But sometimes, it hits the wrong target. Autoimmune diseases like lupus and multiple sclerosis result from friendly fire—immune cells attacking healthy tissues and organs by mistake....
A cigarette habit and previous infection with a common virus both have important effects on the immune system. By Heidi LedfordClose up of a man as he smokes a cigarette in Sundbyberg, near Stockholm.The immune-system signature of cigarette smoking persists for many years after a person kicks the habit.Credit: Jonathan Nackstrand/AFP via Getty The impacts...
by Hokkaido University Compared with untreated cancer, the TRED-I system significantly reduced cancer size in mice models. Credit: Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2310821121A new technology to increase visibility of cancer cells to the immune system using CRISPR has been developed, and could lead to a new way to treat cancer. Major...
by Ludwig Maximilian University of Munich The ASC speck is a central component of the NLRP3 inflammasome. Credit: iScience (2023). DOI: 10.1016/j.isci.2023.108382 A central component of the human immune system, the NLRP3 inflammasome plays an important role in fighting off infections. However, its chronic activation is also implicated in a variety of common diseases, such as...
by Allessandra DiCorato, Broad Institute of MIT and Harvard Cytokine production map by cell type. Credit: Nature (2023). DOI: 10.1038/s41586-023-06816-9 The immune system can carry out many biological processes, from killing viruses to fighting cancer, thanks in large part to approximately 100 key cell-signaling proteins called cytokines, which instruct immune cells what to do. Cytokines are...
