During a 1989 lecture at the Cold Spring Harbor Symposium on Quantitative Biology, Yale School of Medicine professor Charles Janeway, MD, hypothesized the existence of an innate immune system and special receptors on immune cells (currently known as toll-like receptors) that trigger the body’s response to infection. Janeway’s research later confirmed his insights, providing the...
As advanced as medical science is, there are still many diseases we cannot treat. For example, there is no cure for COVID-19. However, this doesn’t mean that we cannot help people recover from this disease. Scientists at the University of Waterloo have found that type-2 diabetes helps stopping the spread of the COVID-19 virus in...
by Emily Ayshford, University of Chicago More than 1.7 million Americans develop sepsis each year, and more than 270,000 die from it. The condition—which happens when the body has an extreme response to a bacterial or viral infection, causing a chain reaction that can lead to organ failure and death—has few strategies for treatment. That’s...
by Tamara Hew-Butler and Mariane Fahlman, The Conversation So here we are, perfecting our social distancing skills while schools, sports and other forms of social engagement are on indefinite hold, by a dangerous virus named after a (regal) crown. The coronavirus is named because the center envelope is surrounded by small protein spikes called peplomers....
Short supplies and limits on who qualifies mean more options are needed to end the pandemic Remdesivir production Gilead Sciences plans to ramp up production of remdesivir, one of the first antiviral drugs to help COVID-19 patients recover, in order to provide 1 million 10-day course of treatment by year’s end. GILEAD SCIENCES Share this:...
A new study shows that when specific human brain cells are transplanted into animal models of multiple sclerosis and other white matter diseases, the cells repair damage and restore function. The study provides one of the final pieces of scientific evidence necessary to advance this treatment strategy to clinical trials. “These findings demonstrate that through...
by Sarah Avery, Duke University As many people know, bladder infections can be a painful and recurring condition, and those who are prone to the infections often report they have to “go” with greater frequency and urgency. These two related conditions are caused by an aberrant immune response that prioritizes repairing tissue in the bladder...
Scientists from the Antibody and Vaccine group at the University of Southampton have discovered a way to transform antibody drugs previously developed to treat autoimmunity into antibodies with powerful anti-cancer activity through a simple molecular “switch”. This work, published in the journal Cancer Cell, focuses on a molecule called CD40 which is present on the...
A new research study headed by Aarhus University in Denmark identifies how viruses avoid the body’s immune system and cause infections and diseases. Viruses have an exceptional ability to circumvent the body’s immune system and cause diseases. The majority of people recover from a viral infection such as influenza, although the current COVID-19 pandemic demonstrates...
Expanding the Organismal Proteostasis Network: Linking Systemic Stress Signaling with the Innate Immune Response Jay Miles Ruth Scherz-Shouval Patricija van Oosten-Hawle Open AccessPublished:July 11, 2019DOI:https://doi.org/10.1016/j.tibs.2019.06.009 PlumX Metrics Previous Article Nature and Regulation of Protein Folding on th … Next Article Analysis and Interpretation of Protein Post-Translational M … Highlights Keywords The Cellular and Organismal Proteostasis...
