By JOE PINKSTONE FOR MAILONLINE German hospital assessed the hormone levels of 45 COVID-19 patients in ICU Found that the vast majority of men admitted had low testosterone levels Testosterone may be able to stop the body’s immune system from going haywire Low levels of the sex hormone are unable to regulate the body’s immune...
Scientists at the Kennedy Institute of Rheumatology in the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences have discovered a new way for T cells to attack cells infected by viruses or deranged by cancer. Published online by the journal Science on Thursday 7 May 2020, the new research from the Dustin Group describes the...
Research begins to pick apart the mechanisms behind a deadly COVID-19 complication. Purple rashes, swollen legs, clogged catheters and sudden death — blood clots, large and small, are a frequent complication of COVID-19, and researchers are just beginning to untangle why. For weeks, reports have poured in of the disease’s effects throughout the body, many...
by University of Pittsburgh Chronic rejection of transplanted organs is the leading cause of transplant failure, and one that the field of organ transplantation has not overcome in almost six decades since the advent of immunosuppressive drugs enabled the field to flourish. Now, a new discovery led by researchers at the University of Pittsburgh School...
Both old and young people can get COVID-19. However, healthy young people usually get better without any treatment at all, while older patients can experience some life-threatening complications. Why older people are at higher risk of more difficult COVID-19 cases? Scientists from ETH Zurich have a good hypothesis. As you get older, your immune system...
by Karolinska Institutet In severe cases of COVID-19, a massive release of the endogenous protein HMGB1 in the lungs may contribute to pulmonary inflammation and tissue damage, according to a review article published today in the scientific journal Molecular Medicine. The researchers conclude that the inflammation could hypothetically be treated with an HMGB1 inhibitor. Severe...
CINCINNATI – After 20 years of trying, modern medicine remains unable to lower the roughly 40 percent mortality rate for the severe childhood immune disease called HLH (hemophagocytic lymphohistiocytosis), which damages vital organs and tissues. Now, researchers report in the New England Journal of Medicine treating patients with a new drug that saved kid’s lives...
Philadelphia, April 29, 2020–Patients with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma now have a new treatment option–a combination of the targeted agent ibrutinib with the immunologic agent rituximab. The U.S. Food and Drug Administration (FDA) has approved the combination based on data from E1912, a phase 3 trial developed and led by...
by Peter MacCallum Cancer Centre Researchers from Peter Mac have discovered an innovative way to dampen severe inflammation in mice, uncovering a potential new therapeutic approach for inflammatory and autoimmune conditions such as arthritis, psoriasis and liver disease, as well as some cancers. The research, co-led by Prof Mark Dawson’s laboratory, in collaboration with scientists...
by E.j. Mundell, Healthday Reporter For many COVID-19 patients battling for their lives in the ICU, a runaway immune system response—known as a “cytokine storm”—is their primary foe. Doctors have few tools to help tame this hyperinflammatory condition, but early research is suggesting that nanotechnology might safely deliver drugs to affected tissues, quieting the storm....
