by University of Pittsburgh Credit: CC0 Public Domain As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells—which have lost their cancer-fighting oomph—consume this lactic acid, which further saps their energy, according to new research from the University of Pittsburgh and UPMC Hillman Cancer Center. When...
Tag: <span>Immunotherapy</span>
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Antibody that reduces inflammation may serve as cardio-immunotherapy for heart failure patients
by Washington University School of Medicine Researchers at WashU Medicine have reduced scar formation and improved heart function in mouse models of heart failure using a monoclonal antibody treatment. Untreated mice develop major scarring after cardiac injury (purple tissue, left) while treated animals show much less scarring (right). The findings point to the possibility of developing...
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Researchers propose a new treatment for brain metastasis based on immunotherapy
October 2, 2024 by The Spanish National Cancer Research Centre Cells around a brain metastasis in an animal model: several brain cells (astrocytes, white) surround an immune system cell (lymphocyte, green). Some of them have started to activate the factor (red) inducing molecule TIMP1, which will enable them to disable the action of the lymphocyte...
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Immunotherapy for gum disease? Study in mice shows promise
September 30, 2024 by University of Pittsburgh Microparticles containing the immune-modulating compound CCL2. Credit: Julie Kobyra, University of PittsburghTargeting the immune system could prevent or treat periodontal disease (PD), a common but serious disease of the gums, according to new research from the University of Pittsburgh. The study, published in Proceedings of the National Academy...
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Disrupting Asxl1 gene prevents T-cell exhaustion to improve immunotherapy, researchers discover
Core epigenetic regulators in maintaining therapeutic durable multipotent Tpex populations. Credit: Science (2024). DOI: 10.1126/science.adl4492 Immunotherapy, using a patient’s own immune system to treat disease, has shown promise in some patients with cancer but has not worked in most. New research from St. Jude Children’s Research Hospital and colleagues has found that disrupting Asxl1, a gene in...
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Combination treatment improves response to immunotherapy for lung cancer, mouse study shows
September 25, 2024 by The Francis Crick Institute Credit: Pixabay/CC0 Public DomainResearchers at the Francis Crick Institute, in collaboration with Revolution Medicines, have tested a combination of treatments in mice with lung cancer and shown that these allow immunotherapies to target non-responsive tumors. Their findings show that targeting tumors in different ways simultaneously might increase...
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Drug bypasses suppressive immune cells to unleash immunotherapy
August 6, 2024 by Marta Wegorzewska, Washington University School of Medicine Immunobiologists Robert Schreiber, Ph.D., (left) and Hussein Sultan, Ph.D., of Washington University School of Medicine in St. Louis, found that a subset of immune cells that normally puts the brakes on the immune system to prevent it from attacking the body’s healthy cells inadvertently...
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Research finds the protein VISTA directly blocks T cells from functioning in immunotherapy
by Cleveland Clinic MAY 17, 2024 Credit: Pixabay/CC0 Public Domain A Cleveland Clinic-led team of scientists and physicians have discovered that the immune checkpoint protein VISTA can directly turn off tumor-fighting T-cells during immunotherapy and resist treatment. The study, published in Science Immunology, explains that VISTA can bind to a protein called LRIG1 in T...
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Immunotherapy Could Be Used To Boost the Immune System of Older Individuals
Immunotherapy could be used to enhance immune responses in older people, making them less vulnerable to infections. News Published: May 16, 2024 | Original story from the University of Minnesota Credit: Congerdesign/ Pixabay Published in Nature Aging, University of Minnesota Medical School researchers provided new insight into enhancing immune responses in older individuals and the...
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New microbiome insights could help boost immunotherapy for a range of rare cancers
by Wellcome Trust Sanger Institute Credit: Unsplash/CC0 Public DomainThe microbiome can identify those who benefit from combination immunotherapy across multiple different cancers, including rare gynecological cancers, biliary tract cancers and melanoma. Researchers from the Wellcome Sanger Institute, the Olivia Newton-John Cancer Research Institute in Australia, and collaborators have identified specific strains of bacteria that are linked...