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Cholangiocyte Biology and Its Implications in Cholangiopathies
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Cholangiocyte Biology and Its Implications in Cholangiopathies

By Dr. Priyom Bose, Ph.D.Reviewed by Danielle Ellis, B.Sc. The biliary system comprises extrahepatic bile ducts, intrahepatic bile ducts, and the gallbladder. The intrahepatic and extrahepatic biliary tree is lined with epithelial cells known as cholangiocytes. These epithelial cells are associated with vital physiologic processes that are crucial for normal body functioning. Considering the importance...

Mechanical forces in a beating heart affect its cells’ DNA, with implications for development and disease
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Mechanical forces in a beating heart affect its cells’ DNA, with implications for development and disease

by Corey Neu, The Conversation Contracting heart cells exert forces on their genetic material that affect how they develop. Credit: Benjamin Seelbinder, CC BY-ND Sometimes cells can forget what type of cell they are and stop functioning correctly. This commonly happens in cancer, in which mature cells lose aspects of their identity and become more susceptible to begin...