by La Trobe University a, b Deletion of BECLIN1, but not ATG7, by addition of 4-hydroxytamoxifen (4-HT) led to significantly smaller intestinal organoids. a, c There was also a significant reduction in the number of “buds” per organoid formed, indicative of reduced stem cell-containing crypt formation. Credit: Communications Biology (2024). DOI: 10.1038/s42003-024-05890-7La Trobe University researchers have...
Tag: <span>inflammatory bowel disease</span>
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Mucus contains vital data to help address diseases such as inflammatory bowel disease and colon cancer
by University of British Columbia Visualizing and quantifying mucus barrier functions on fecal sections. a. Processing scheme for processing feces for mucus analysis in situ. b. Tiled cross-section of healthy human feces (upper) and mouse feces (lower) dual stained with FISH probes (red) and a rabbit polyclonal antibody targeting human MUC2 (see Methods; green). c. Quantitative...
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Study identifies promising target for treating inflammatory bowel disease and colitis-induced colorectal cancers
by Will Cushman, University of Wisconsin-Madison This image shows the effect of pro-inflammatory cytokines on the growth of a mouse intestinal organoid. Intestinal stem cells (red) are indicative of inflammation and Ki67 proteins (green) are associated with tumors. Credit: Ting FuInflammation in the gut can trigger a doom loop of sorts. The condition messes with the...
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Body changes detected up to eight years before inflammatory bowel disease diagnosis
by The Francis Crick Institute Credit: CC0 Public Domain Researchers at the Francis Crick Institute and Aalborg University in Copenhagen have shown that changes can be detected in blood tests up to eight years before a diagnosis of Crohn’s disease and up to three years before a diagnosis of ulcerative colitis. This means the beginnings of...
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Intestinal ultrasound monitoring cuts time to treatment change in inflammatory bowel disease
by Elana Gotkine For patients with inflammatory bowel disease (IBD), monitoring by intestinal ultrasound (IUS) results in reduced time to treatment change and to remission, according to a study presented at the annual meeting of the American College of Gastroenterology, held from Oct. 20 to 25 in Vancouver, British Columbia, Canada. Noa Krugliak Cleveland, M.D.,...
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Novel biologic Ab-IPL-IL-17 shows promise for rheumatoid arthritis and inflammatory bowel disease
by University of Birmingham Credit: Pixabay/CC0 Public Domain Researchers have shown that a novel antibody generated to target an ‘essential amino acid sequence’ of both interleukin-17A and F has greater activity and potentially fewer side effects than existing biological therapies for conditions such as as rheumatoid arthritis (RA), psoriasis, and inflammatory bowel disease (IBD). The antibody, called...
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Lower fiber intake tied to higher risk for later inflammatory bowel disease
by Lori Solomon Higher consumption of dietary fiber was associated with a lower risk for inflammatory bowel disease (IBD), according to a study published online July 18 in Alimentary Pharmacology and Therapeutics. Minzi Deng, Ph.D., from Central South University in Changsha, China, and colleagues examined associations between dietary fiber intake and subsequent incidence of IBD, Crohn disease, and ulcerative...
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Inflammatory bowel disease linked to increased risk of stroke
by American Academy of Neurology Credit: CC0 Public Domain People with inflammatory bowel disease (IBD) are more likely to have a stroke than people without the disease, according to a study published in Neurology. The study does not prove that IBD causes stroke; it only shows an association. Inflammatory bowel disease causes chronic inflammation of the intestines....
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Frequent use of antibiotics may heighten inflammatory bowel disease risk in adults over 40
by British Medical Journal Credit: Pixabay/CC0 Public Domain Frequent use of antibiotics may heighten the risk of inflammatory bowel disease—Crohn’s disease and ulcerative colitis—among adults over 40, suggests research published online in the journal Gut. The risk seems to be cumulative and greatest 1-2 years after use and for those antibiotics targeting gut infections, the findings indicate. Mounting...
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Red food dye found in Doritos, Skittles and Pepsi can trigger inflammatory bowel disease, study warns
By CASSIDY MORRISON SENIOR HEALTH REPORTER FOR DAILYMAIL.COM PUBLISHED: 12:10 EST, 20 December 2022 | UPDATED: 07:26 EST, 21 December 2022 A food dye found in dozens of family favorite snacks may trigger severe bowel diseases, scientists warn. Red 40, also known as Allura red, is in several popular candies, sodas and chips – including Doritos, Skittles, and Pepsi...