by Germans Trias i Pujol Research Institute Immune dysregulation and barrier dysfunction in the pathogenesis of inflammatory bowel disease (IBD). The disruption of intestinal homeostasis in IBD is driven by dysbiosis in the gut lumen, loss of the mucus layer, and increased epithelial permeability, allowing bacterial translocation into the lamina propria. Breaches in the epithelial...
Tag: <span>inflammatory bowel disease</span>
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Biomarker identified for predicting inflammatory bowel disease treatment success
by Charité – Universitätsmedizin Berlin Multimodal characterization of patients with IBD receiving anti-integrin α4β7. Credit: Gastroenterology (2024). DOI: 10.1053/j.gastro.2024.09.021 Not everyone responds equally well to treatments for inflammatory bowel disease (IBD). What will work for individual patients involves trial and error during the treatment process. Now, a team of researchers led by Charité—Universitätsmedizin, in collaboration with colleagues in...
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Refined dietary fiber may increase risk for inflammatory bowel disease
September 10, 2024 by Brooke Pier, Pennsylvania State University Guar gum exacerbated DSS-induced acute colitis. Credit: Gut Microbes (2024). DOI: 10.1080/19490976.2024.2341457For many people, an enjoyable summer staple food is a scoop of their favorite ice cream. What they may not know is that this creamy treat often contains refined dietary fibers, such as guar gum,...
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Gut reaction: Low levels of manganese can aggravate inflammatory bowel disease
September 12, 2024 by Kim North Shine, University of Michigan Slc39a8 mediates the uptake of 54Mn at the apical membrane of intestinal organoid monolayer culture. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-49049-8Researchers at the University of Michigan have delved deeper into the relationship between manganese deficiency and inflammatory bowel disease and found that low levels of...
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Vitamin B1 linked to reduced fatigue in some inflammatory bowel disease patients
September 3, 2024 by Aarhus University Graphical abstract. Credit: Gastro Hep Advances (2024). DOI: 10.1016/j.gastha.2024.08.012Fatigue is a common and often debilitating companion for people with inflammatory bowel conditions. Now, a new Danish study provides insight into why vitamin B1—also known as thiamine—helps some patients regain their energy, while others do not experience the same effect....
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Novel PET imaging tool identifies early signs of inflammatory bowel disease and predicts response to treatment
July 25, 2024 by Society of Nuclear Medicine and Molecular Imaging Visual Abstract. Active bowel inflammation disrupts the bowel cell lining, which causes the inflammatory T cells to secrete Granzyme B into the extracellular space, progressively accentuating the inflammatory response through a feed-forward mechanism. In the normal or non-inflamed bowel, there is no extracellular Granzyme...
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Researchers identify protein integral to gut health, may lead to treatments for inflammatory bowel disease
by La Trobe University a, b Deletion of BECLIN1, but not ATG7, by addition of 4-hydroxytamoxifen (4-HT) led to significantly smaller intestinal organoids. a, c There was also a significant reduction in the number of “buds” per organoid formed, indicative of reduced stem cell-containing crypt formation. Credit: Communications Biology (2024). DOI: 10.1038/s42003-024-05890-7La Trobe University researchers have...
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Mucus contains vital data to help address diseases such as inflammatory bowel disease and colon cancer
by University of British Columbia Visualizing and quantifying mucus barrier functions on fecal sections. a. Processing scheme for processing feces for mucus analysis in situ. b. Tiled cross-section of healthy human feces (upper) and mouse feces (lower) dual stained with FISH probes (red) and a rabbit polyclonal antibody targeting human MUC2 (see Methods; green). c. Quantitative...
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Study identifies promising target for treating inflammatory bowel disease and colitis-induced colorectal cancers
by Will Cushman, University of Wisconsin-Madison This image shows the effect of pro-inflammatory cytokines on the growth of a mouse intestinal organoid. Intestinal stem cells (red) are indicative of inflammation and Ki67 proteins (green) are associated with tumors. Credit: Ting FuInflammation in the gut can trigger a doom loop of sorts. The condition messes with the...
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Body changes detected up to eight years before inflammatory bowel disease diagnosis
by The Francis Crick Institute Credit: CC0 Public Domain Researchers at the Francis Crick Institute and Aalborg University in Copenhagen have shown that changes can be detected in blood tests up to eight years before a diagnosis of Crohn’s disease and up to three years before a diagnosis of ulcerative colitis. This means the beginnings of...