New insights highlight the potential for circadian clock modulation in IBD treatment per-Reviewed Publication THE HEBREW UNIVERSITY OF JERUSALEM This study highlights the critical role of the body’s circadian clock in regulating immune activity and digestive functions, revealing its influence on the development and progression of inflammatory bowel diseases (IBDs) such as Crohn’s disease and...
Tag: <span>inflammatory bowel disease</span>
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Inflammatory bowel disease can be detected in blood samples up to 16 years before onset, study suggests
by Örebro Universitet Credit: Gastroenterology (2024). DOI: 10.1053/j.gastro.2024.11.006 Scientists at Örebro University have identified specific protein patterns in blood tests that can predict inflammatory bowel disease (IBD) up to 16 years before diagnosis. In particular, Crohn’s disease can be detected with very high accuracy. The study has been published in Gastroenterology. “We’ve taken an important step towards us being able...
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Extracellular vesicles may be key to developing safer and more effective therapies for inflammatory bowel disease
by Germans Trias i Pujol Research Institute Immune dysregulation and barrier dysfunction in the pathogenesis of inflammatory bowel disease (IBD). The disruption of intestinal homeostasis in IBD is driven by dysbiosis in the gut lumen, loss of the mucus layer, and increased epithelial permeability, allowing bacterial translocation into the lamina propria. Breaches in the epithelial...
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Biomarker identified for predicting inflammatory bowel disease treatment success
by Charité – Universitätsmedizin Berlin Multimodal characterization of patients with IBD receiving anti-integrin α4β7. Credit: Gastroenterology (2024). DOI: 10.1053/j.gastro.2024.09.021 Not everyone responds equally well to treatments for inflammatory bowel disease (IBD). What will work for individual patients involves trial and error during the treatment process. Now, a team of researchers led by Charité—Universitätsmedizin, in collaboration with colleagues in...
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Refined dietary fiber may increase risk for inflammatory bowel disease
September 10, 2024 by Brooke Pier, Pennsylvania State University Guar gum exacerbated DSS-induced acute colitis. Credit: Gut Microbes (2024). DOI: 10.1080/19490976.2024.2341457For many people, an enjoyable summer staple food is a scoop of their favorite ice cream. What they may not know is that this creamy treat often contains refined dietary fibers, such as guar gum,...
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Gut reaction: Low levels of manganese can aggravate inflammatory bowel disease
September 12, 2024 by Kim North Shine, University of Michigan Slc39a8 mediates the uptake of 54Mn at the apical membrane of intestinal organoid monolayer culture. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-49049-8Researchers at the University of Michigan have delved deeper into the relationship between manganese deficiency and inflammatory bowel disease and found that low levels of...
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Vitamin B1 linked to reduced fatigue in some inflammatory bowel disease patients
September 3, 2024 by Aarhus University Graphical abstract. Credit: Gastro Hep Advances (2024). DOI: 10.1016/j.gastha.2024.08.012Fatigue is a common and often debilitating companion for people with inflammatory bowel conditions. Now, a new Danish study provides insight into why vitamin B1—also known as thiamine—helps some patients regain their energy, while others do not experience the same effect....
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Novel PET imaging tool identifies early signs of inflammatory bowel disease and predicts response to treatment
July 25, 2024 by Society of Nuclear Medicine and Molecular Imaging Visual Abstract. Active bowel inflammation disrupts the bowel cell lining, which causes the inflammatory T cells to secrete Granzyme B into the extracellular space, progressively accentuating the inflammatory response through a feed-forward mechanism. In the normal or non-inflamed bowel, there is no extracellular Granzyme...
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Researchers identify protein integral to gut health, may lead to treatments for inflammatory bowel disease
by La Trobe University a, b Deletion of BECLIN1, but not ATG7, by addition of 4-hydroxytamoxifen (4-HT) led to significantly smaller intestinal organoids. a, c There was also a significant reduction in the number of “buds” per organoid formed, indicative of reduced stem cell-containing crypt formation. Credit: Communications Biology (2024). DOI: 10.1038/s42003-024-05890-7La Trobe University researchers have...
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Mucus contains vital data to help address diseases such as inflammatory bowel disease and colon cancer
by University of British Columbia Visualizing and quantifying mucus barrier functions on fecal sections. a. Processing scheme for processing feces for mucus analysis in situ. b. Tiled cross-section of healthy human feces (upper) and mouse feces (lower) dual stained with FISH probes (red) and a rabbit polyclonal antibody targeting human MUC2 (see Methods; green). c. Quantitative...