Tag: <span>Instability</span>

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Chromosomal Instability Drives Cancer Metastasis

Image: When a chromosomally unstable cell divides, its chromosomes can become disordered during anaphase (1). Errors in segregation can allow chromosomes to leak into the cytosol, where they form “micronuclei” (2), which trigger an inflammatory response in the daughter cell (3). This response can lead to metastasis. EDITOR’S CHOICE IN ONCOLOGY Aneuploidy—the presence of abnormal numbers...