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Breaking down fat byproducts could lead to healthier aging: Researchers identify key enzyme that does just that

by Eyleen Jorgelina O’Rourke, The Conversation Triacylglycerols, also known as triglycerides, are composed of a glycerol linked to three fatty acids. Credit: Lumen Learning (formerly Boundless) via LibreTexts, CC BY-SAThe journey of aging brings with it an unavoidable reality for many: an increased accumulation of body fat. Though much of society seems mostly focused on the...

Researchers identify a key enzyme that controls white-to-brown fat conversion
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Researchers identify a key enzyme that controls white-to-brown fat conversion

by Jacqueline Mitchell, Beth Israel Deaconess Medical Center CUL2 controls PRDM16 protein stability and beige fat biogenesis. a, Immunoblotting of Flag-tagged PRDM16 protein in HEK293T cells co-expressing Myc-tagged cullin proteins or an empty vector (Vec). b, Immunoblotting of endogenous PRDM16 protein in inguinal adipocytes overexpressing (OE) Flag-tagged CUL2 or Vec. β-Actin was used as the loading control. c,...

Study identifies key enzyme for development of autoimmune diseases
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Study identifies key enzyme for development of autoimmune diseases

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO IMAGE: IT INCREASES CNS AUTOIMMUNE INFLAMMATION. THE CONFOCAL IMAGE DISPLAYS PKM2 EXPRESSION (IN RED) WITHIN THE INFLAMMATORY CELL INFILTRATE IN THE SPINAL CORD OF MICE SUBJECTED TO EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS. Scientists affiliated with the Center for Research on Inflammatory Diseases, hosted by the University of...