by Tim Tedeschi, University of Cincinnati The prognostic application of metabolic signature and adjacent localization of cancer cells with metabolic and proliferative states support the role of metabolic state in tumor progression. Credit: Cancer Discovery (2024). DOI: 10.1158/2159-8290.CD-24-0187 A new study led by University of Cincinnati Cancer Center researchers details how the accumulation of copper helps clear cell...
Tag: <span>kidney cancer</span>
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New imaging technique accurately detects aggressive kidney cancer
October 3, 2024 by Denise Heady, University of California, Los Angeles A new study led by investigators from the UCLA Health Jonsson Comprehensive Cancer Center has demonstrated a new, non-invasive imaging technique can accurately detect clear-cell renal cell carcinoma, the most common form of kidney cancer. The findings, published in The Lancet Oncology, could greatly...
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New imaging technique accurately detects aggressive kidney cancer
Representative imaging with [89Zr]Zr-girentuximab. Credit: The Lancet Oncology (2024). DOI: 10.1016/S1470-2045(24)00402-9 A new study led by investigators from the UCLA Health Jonsson Comprehensive Cancer Center has demonstrated a new, non-invasive imaging technique can accurately detect clear-cell renal cell carcinoma, the most common form of kidney cancer. The findings, published in The Lancet Oncology, could greatly reduce the number...
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Gene mutations linked to hereditary kidney cancer predisposition but potential Achilles’ heel identified
UNIVERSITY OF CALIFORNIA – LOS ANGELES HEALTH SCIENCES Researchers at the UCLA Jonsson Comprehensive Cancer Center have confirmed that a large number of genetic variants of unknown significance are in fact verified mutations that predispose patients to a rare hereditary syndrome that increases the risk of kidney cancer. By functionally characterizing the behavior of these mutations, researchers and...
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Researchers ID biomarkers of response to immunotherapy for kidney cancer
by Johns Hopkins University School of Medicine Pathologists look through a microscope to evaluate H&E slides for tumor infiltrating immune cells and necrosis in patients with kidney cancer who go on to receive immunotherapy. Credit: Julie Stein Deutsch via Biorender The number of immune cells in and around kidney tumors, the amount of dead cancer...
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Combination therapy a promising option for advanced kidney cancer patients already treated with immunotherapy
by Dana-Farber Cancer Institute Credit: Unsplash/CC0 Public Domain Immunotherapies, such as anti-PD-1 and anti-PD-L1, have become standard first line therapies for patients with advanced renal cell carcinoma (kidney cancer). Most patients, however, eventually experience disease progression, with no consensus on what therapy to use next. In an open-label phase 2 study, led by Dana-Farber Cancer...
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Gene signature points to prognosis in kidney cancer
KAROLINSKA INSTITUTET Among patients with kidney cancer, the activity of four specific genes in the cancer cells seems to be able to predict the risk of the tumour spreading and the patient’s chances of survival. This is shown by researchers from Karolinska Institutet in Sweden in a preclinical study published in Nature Communications. “This could potentially...
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Deliberately damaging DNA could boost the effectiveness of immunotherapy in kidney cancer
by Institute of Cancer Research Cancer cell being attacked by two immune cells. Credit: NIH Image Gallery, CC BY 2.0 DNA damage is one of the foundational causes of cancer. But researchers have now found that deliberately causing DNA damage—by delivering additional treatments like radiotherapy—could improve the effectiveness of immunotherapy for some people with kidney...
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Three-drug combination slows progression of advanced kidney cancer
by Dana-Farber Cancer Institute Credit: CC0 Public Domain A targeted kinase inhibitor added to a two-drug immunotherapy combination slowed the progression of advanced kidney cancer in previously untreated patients, according to research led by an oncologist from Dana-Farber Cancer Institute. “Patients who received the kinase inhibitor cabozantinib in addition to checkpoint-blockers nivolumab and ipilimumab experienced...
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Can kidney cancer be mistaken for kidney stones?
Kidney cancer shares some similar symptoms with kidney stones, including blood in the urine, lower back pain, and fatigue. Due to these similarities, some medical professionals may incorrectly diagnose kidney cancer as kidney stones. Kidney cancer is one of the 10 most common cancers in people. Kidney cancer shares some symptoms with kidney stones, which...