September 18, 2024 by Elana Gotkine A new prognostic model can predict and stratify hepatocellular carcinoma (HCC) risk in noncirrhotic adult patients with chronic hepatitis B (CHB), according to a study published online Sept. 17 in the Annals of Internal Medicine. Gi-Ae Kim, M.D., Ph.D., from Kyung Hee University Hospital in Seoul, South Korea, and...
JUNE 24TH, 2024POSTED BY ROCKEFELLER UNIVERSITY A microscopy image of single cell spatial transcriptomics of FLC tumor cells (red) and stellate cells (green); the latter generates fibrous bands of collagen in response to the FLC cells. (Credit: Rockefeller) TAGS : CANCERLIVERSUNIVERSITY : ROCKEFELLER UNIVERSITY New research sheds light on a rare form of cancer called...
by UC Davis Credit: Pixabay/CC0 Public DomainA team of UC Davis Health clinicians and data scientists has developed a machine-learning model to better predict which patients are at greater risk of developing a common type of liver cancer, hepatocellular carcinoma (HCC). The findings of their research—published in the journal Gastro Hep Advances—describe how predictive-learning can aid...
The idea of injecting microscopic robots into the bloodstream to heal the human body is not new. It’s also not science fiction. Guided by an external magnetic field, miniature biocompatible robots, made of magnetizable iron oxide nanoparticles, can theoretically provide medical treatment in a very targeted manner. Until now, there has been a technical obstacle:...
by Krista Conger, Stanford University Medical Center Collagen fibers in a three-dimensional hydrogel (left panel). When advanced glycation end products—a byproduct of poorly controlled diabetes—are added (right), the fibers are shorter and more cross-linked, creating conditions that favor cancer progression. Credit: Weiguo FanFor centuries, doctors have used their hands as essential diagnostic tools—exploring joints and palpating...
The research, led by the Keck School of Medicine of USC, analyzed risk for the disease across more than 30,000 Mexican Americans, finding third-generation Mexican Americans 66% more likely to get liver cancer than the first generation.Peer-Reviewed Publication KECK SCHOOL OF MEDICINE OF USC In the United States, liver cancer rates have more than tripled...
by UC Davis Graphical Abstract. Credit: Molecular Therapy (2023). DOI: 10.1016/j.ymthe.2023.04.019 Gene therapy that induces the body to create microRNA-22 (miR-22), a naturally occurring molecule, successfully treated mice with hepatocellular carcinoma, the most common form of liver cancer. The miR-22 treatment also reduced liver inflammation and produced better survival outcomes with no observable toxicity compared...
by The Mount Sinai Hospital The study revealed how certain immune cell interactions in tumors facilitate response to checkpoint blockade, pointing to potential new approaches to cancer immunotherapy. Credit: Magen et al., Nature Medicine Researchers at the Icahn School of Medicine at Mount Sinai have uncovered a trio of immune cells within tumor niches that are associated with...
by Josep Carreras Leukaemia Research Institute NSUN7 epigenetic loss occurs in human primary HCC tumors in association with worse clinical outcome. (A) Percentage of NSUN7 methylation in the TCGA data set of primary tumors according to cancer type. (B) NSUN7 methylation is inversely correlated with NSUN7 transcript expression in TCGA HCC tumors. (C) NSUN7 methylation is...
UNIVERSITY OF CALIFORNIA – SAN DIEGO IMAGE: UC SAN DIEGO SCIENTISTS FIND THE PROTEIN ATF4 PREVENTS LIVER DAMAGE AND ITS PROGRESSION TO CANCER BY BLOCKING FERROPTOSIS, AN IRON-DEPENDENT FORM OF LIVER CELL DEATH. CREDIT: UC SAN DIEGO HEALTH SCIENCES Liver cancer is the third leading cause of cancer death and the sixth most common cancer...
