by Osaka Metropolitan University Graphical abstract. Credit: American Journal of Physiology-Gastrointestinal and Liver Physiology (2024). DOI: 10.1152/ajpgi.00134.2024 Chronic liver damage can lead to hepatitis, which causes fibrosis of the liver. This buildup of collagen and other fibrous tissue accelerates when hepatic stellate cells become activated during hepatitis, often resulting in liver cancer or cirrhosis, both of which can...
Tag: <span>liver fibrosis</span>
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A simple plasma-based biomarker could predict liver fibrosis in Latino adolescents with obesity
by Children’s Hospital Los Angeles Credit: Pixabay/CC0 Public Domain A recent study led by Principal Investigator Michael Goran, Ph.D., and Rachel Schenker, MD, a Fellow in the Children’s Hospital Los Angeles Liver Transplant Program, has found a novel combination of plasma-based biomarkers that could potentially predict liver fibrosis—scarring due to long-term inflammation or damage—linked to metabolic...
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Dual screening in diabetes: Liver fibrosis and eye disease detection
by Karolinska Institutet Credit: Unsplash/CC0 Public Domain New research from Karolinska Institutet in Sweden highlights the possibility of screening people with type 2 diabetes for liver damage at the same time as they undergo screening for eye disease. The study “Screening for advanced liver fibrosis due to metabolic dysfunction-associated steatotic liver disease alongside retina scanning in...
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Scientists successfully reverse liver fibrosis in mice
by Ernie Mundell Cirrhosis, hepatitis infection and other causes can trigger liver fibrosis—a potentially lethal stiffening of tissue that, once begun, is irreversible. For many patients, a liver transplant is their only hope. However, research at Cedars-Sinai in Los Angeles may offer patients a glimmer of hope. Scientists there say they’ve successfully reversed liver fibrosis...
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Q&A: Study identifies potential new treatment for liver fibrosis
September 25, 2024 by University of Pittsburgh Microscopy image showing activated hepatic stellate cells (HSCs), indicated by red staining (left image). Inhibition of CYB1B1 reduces HSC activation (right image), which leads to reduced liver fibrosis. Credit: Tung et al., Science Translational Medicine. 16, eadk8446 (2024)New research from the University of Pittsburgh School of Pharmacy sheds...
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New technique could improve liver fibrosis treatment
by First Hospital of Jilin University Locally estimated scatter plot smoothing estimated risk of steatosis (panels A and B) and advanced fibrosis (panels C and D) according to the CLivDlab and CLivDnon-lab scores. The shaded area represents 95% CIs. The dashed vertical lines show the cutoffs of the CLivD score separating minimal-risk, low-risk, intermediate-risk and...
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Hormones have the potential to treat liver fibrosis, new study finds
by Birgitte Svennevig, University of Southern Denmark Graphical Abstract. Credit: Journal of Hepatology (2023). DOI: 10.1016/j.jhep.2023.11.001Hormone therapy may be associated with menopause and fertility treatment, but now an SDU-led research team reports that certain intestinal hormones seem to have a beneficial effect on the processes behind the formation of scar tissue in the liver (liver...
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From soft tissue to stiff leather: Understanding the role of paxillin in liver fibrosis
by Medical University of South Carolina Paxillin localization during HSC activation. (A) HSCs were isolated, grown on glass coverslips for 7 days, and fixed. Paxillin was labeled at the specified time points as described in the Materials and Methods. DAPI was used to label nuclei. The boxes in row 3 of the panel illustrate magnified area in...
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Liver fibrosis linked to reduced cognitive ability and brain volume
by Mallory Locklear, Yale University Summary of cohort characteristics at baseline and analyses performed in the current study. (A) The current study incorporated up to 447,626 participants who have complete data for liver fibrosis scores, covariate variables, and at least one cognitive test at baseline. The severity of liver fibrosis was calculated using the Fibrosis-4 (Fib-4)...
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The hidden power of Japanese food: Inhibiting the development of liver fibrosis
by Osaka Metropolitan University Researchers analyzed the relationship between meals rated by the 12-component modified Japanese Diet Index (mJDI12), muscle mass, and liver fibrosis progression in 136 patients with nonalcoholic fatty liver disease (NAFLD) attending the Osaka Metropolitan University Hospital. Credit: Osaka Metropolitan University Japanese food is popular worldwide and has been registered as a UNESCO Intangible Cultural...
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