by Ernie Mundell Cirrhosis, hepatitis infection and other causes can trigger liver fibrosis—a potentially lethal stiffening of tissue that, once begun, is irreversible. For many patients, a liver transplant is their only hope. However, research at Cedars-Sinai in Los Angeles may offer patients a glimmer of hope. Scientists there say they’ve successfully reversed liver fibrosis...
Tag: <span>liver fibrosis</span>
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Q&A: Study identifies potential new treatment for liver fibrosis
September 25, 2024 by University of Pittsburgh Microscopy image showing activated hepatic stellate cells (HSCs), indicated by red staining (left image). Inhibition of CYB1B1 reduces HSC activation (right image), which leads to reduced liver fibrosis. Credit: Tung et al., Science Translational Medicine. 16, eadk8446 (2024)New research from the University of Pittsburgh School of Pharmacy sheds...
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New technique could improve liver fibrosis treatment
by First Hospital of Jilin University Locally estimated scatter plot smoothing estimated risk of steatosis (panels A and B) and advanced fibrosis (panels C and D) according to the CLivDlab and CLivDnon-lab scores. The shaded area represents 95% CIs. The dashed vertical lines show the cutoffs of the CLivD score separating minimal-risk, low-risk, intermediate-risk and...
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Hormones have the potential to treat liver fibrosis, new study finds
by Birgitte Svennevig, University of Southern Denmark Graphical Abstract. Credit: Journal of Hepatology (2023). DOI: 10.1016/j.jhep.2023.11.001Hormone therapy may be associated with menopause and fertility treatment, but now an SDU-led research team reports that certain intestinal hormones seem to have a beneficial effect on the processes behind the formation of scar tissue in the liver (liver...
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From soft tissue to stiff leather: Understanding the role of paxillin in liver fibrosis
by Medical University of South Carolina Paxillin localization during HSC activation. (A) HSCs were isolated, grown on glass coverslips for 7 days, and fixed. Paxillin was labeled at the specified time points as described in the Materials and Methods. DAPI was used to label nuclei. The boxes in row 3 of the panel illustrate magnified area in...
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Liver fibrosis linked to reduced cognitive ability and brain volume
by Mallory Locklear, Yale University Summary of cohort characteristics at baseline and analyses performed in the current study. (A) The current study incorporated up to 447,626 participants who have complete data for liver fibrosis scores, covariate variables, and at least one cognitive test at baseline. The severity of liver fibrosis was calculated using the Fibrosis-4 (Fib-4)...
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The hidden power of Japanese food: Inhibiting the development of liver fibrosis
by Osaka Metropolitan University Researchers analyzed the relationship between meals rated by the 12-component modified Japanese Diet Index (mJDI12), muscle mass, and liver fibrosis progression in 136 patients with nonalcoholic fatty liver disease (NAFLD) attending the Osaka Metropolitan University Hospital. Credit: Osaka Metropolitan University Japanese food is popular worldwide and has been registered as a UNESCO Intangible Cultural...
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RNA Lipid Nanoparticle Engineering Stops Liver Fibrosis in its Tracks, Reverses Damage
Since the success of the COVID-19 vaccine, RNA therapies have been the object of increasing interest in the biotech world. These therapies work with your body to target the genetic root of diseases and infections, a promising alternative treatment method to that of traditional pharmaceutical drugs Lipid nanoparticles (LNPs) have been successfully used in drug delivery...
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RNA lipid nanoparticle engineering stops liver fibrosis in its tracks, reverses damage
by Melissa Pappas, University of Pennsylvania Preparation and application of ligand-tethered lipidoid nanoparticles for targeted siRNA delivery to HSCs to treat liver fibrosis. a Formulation of AA-T3A-C12/siHSP47 LNP via microfluidic mixing. The ethanol lipid solution containing anisamide-tethered lipidoid (AA-T3A-C12), phospholipid (DSPC), PEG-lipid (C14-PEG), and cholesterol is rapidly mixed with an acidic aqueous solution containing HSP47 siRNA in a...
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Letrozole could be repurposed for the treatment of liver fibrosis, study finds
by Niigata University Letrozole ameliorates liver fibrosis through the inhibition of the CTGF pathway and 17β-hydroxysteroid dehydrogenase 13 expression. Credit: Niigata University A gene expression-based screening assay using chimeric mice with humanized hepatocytes revealed that letrozole has a modifying effect on fibrosis-related gene expression in the hepatocytes, including YAP, CTGF, TGF-β, and CYP26A1. Because of...
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