by Koen Stein, Vrije Universiteit Brussel Panx1-targeting nanobodies interact with the NLRP3 inflammatory cascade in acetaminophen-overdosed mice. a Overview of the NLRP3 signaling cascade in acetaminophen (APAP)-induced hepatotoxicity. Overdosing mice with APAP triggers oxidative metabolization catalyzed by cytochrome (CYP) P450 enzymes in hepatocytes. Associated-NAPQI formation causes necrosis, which triggers a Panx1-mediated inflammatory response in the...
UNIVERSITY OF BARCELONA The RNF41 protein could be a new therapeutic target in the fight against two chronic liver diseases: cirrhosis and liver inflammation. This is stated in a study published in the journal Science Translational Medicine led by researcher Pedro Melgar-Lesmes, from the Department of Biomedicine at the Faculty of Medicine and Health Sciences of the...
Red/orange areas indicate precursors of atherosclerotic plaques called fatty streaks. Inflammatory processes in the liver lead to elevated cholesterol levels in people with diabetes, thus promoting subsequent vascular diseases. This is the result of a study by scientists of Helmholtz Zentrum München, Technische Universität München (TUM) and the Collaborative Research Center SFB 1118 at Heidelberg...
