by Center for Genomic Regulation This shows a cross-section of a mouse lung infected with Pseudonomas aeruginosa. The mouse was treated with a version of Mycoplasma pneumoniae that is able to produce therapeutic molecules such as pyocins specifically-designed to combat P. aeruginosa. This therapeutic version of M. pneumoniae acts like a ‘living medicine’ reducing the...
by Professor Dr. Claudio De Simone, Medical Xpress Ventilated infant. Credit: Alexander Gray on Unsplash Newspaper headlines from the U.S. to the U.K. and most places in between highlight the surge in sick patients suffering from respiratory viruses. The so-called “tripledemic” of lung infections including respiratory synclinal virus (RSV), influenza (flu) and COVID-19 (coronavirus) is...
by Tina Hesman Saey, Washington University School of Medicine in St. Louis Credit: Washington University School of Medicine in St. Louis Three types of fungi that cause serious lung infections and were once thought to be confined to certain regions of the United States are now widespread. In 1955, Histoplasma fungi grew mainly in Midwest soil and...
by Washington University School of Medicine The fungus Histoplasma, which causes lung infections, was concentrated in the Midwest in the 1950s and 60s (top map), but now causes significant disease throughout much of the country (bottom). Researchers at Washington University School of Medicine in St. Louis discovered that the three main kinds of soil fungi...
by Bob Yirka , Medical Xpress Immunological synapses of the Af-CAR T cells (pink) in coculture with A. fumigatus hyphae (grey). Credit: Science Translational Medicine (2022). DOI: 10.1126/scitranslmed.abh1209 An international team of researchers has developed a way to modify the CAR T engineering process to create cells that can assist in fighting fungal infections in the lungs....
By Ben Coxworth September 12, 2022 Manuka honey is produced in Australia and New Zealand by bees that pollinate the tea tree shrub Depositphotos People with cystic fibrosis are vulnerable to potentially fatal Mycobacterium abscessus lung infections, which are notoriously difficult to treat. A new treatment may succeed where others have failed, however – and it utilizes...
IMAGE: BASAL EPITHELIAL STEM CELLS (GREEN) CONTAINING THE PROTEIN IL-33 (RED) ARE VISIBLE IN A SAMPLE OF LUNG TISSUE (PICTURED). RESEARCHERS AT WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IN ST. LOUIS HAVE FOUND THAT SUCH STEM CELLS MULTIPLY DURING AND AFTER A VIRAL RESPIRATORY INFECTION, SOMETIMES TRIGGERING A DETRIMENTAL REMODELING PROCESS THAT CAN CAUSE PERSISTENT LUNG...
UNIVERSITY OF WARWICK Staphylococcus aureus (which includes MRSA) is the most prevalent organism isolated from the airways of children with cystic fibrosis (CF), and is treated using antibiotics, but its role in lung disease is poorly understood Using pig lungs from a butcher and synthetic mucus, researchers from the University of Warwick have shown that S. aureus preferentially colonises mucus,...
by University of Geneva The protein Vav3 (in green) creates «bacterial docking stations» on the surface (in red) of respiratory cells (nuclei in blue) that facilitate airways’ infection in patients with cystic fibrosis. Credit: UNIGE, laboratoire Chanson Cystic fibrosis, one of the most common genetic diseases in Switzerland, causes severe respiratory and digestive disorders. Despite...
Of a small number of patients, 15% died compared with the 85% expected Overall 70% of patients who were on the brink of death saw improvements The researchers admitted they did not expect such positive results The treatment works by injecting patients with cells taken from fat tissue The stem cells are known to bolster...
