KUMAMOTO UNIVERSITY IMAGE: Normally, FLCN keeps the transcription factor TFE3 in the cytoplasm and suppresses the expression of Prox1 in veins. When FLCN is deleted, TFE3 migrates into the nucleus and Prox1 is expressed resulting in the appearance of venous endothelial cells that resemble lymphatic vessels. In other words, FLCN acts as a gatekeeper that regulates the plasticity of blood and...
Tag: <span>lymph vessels</span>
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How to prevent the spread of tumor cells via the lymph vessels
by German Cancer Research Center What role do the lymphatic vessels play in the metastasis of cancer cells? Scientists from the German Cancer Research Center and the Mannheim Medical Faculty of the University of Heidelberg developed a method to investigate this question in mice. The aim of the work was to identify new ways to block the dangerous colonization and...