by University of Vienna Immunofluorescence image of the expression of PHGDH (red) and CD3 T cells (green) in cryosectioned AE17 mesothelioma. Credit: Zhengnan CaiA study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in Cellular & Molecular Immunology, shows that the enzyme phosphoglycerate dehydrogenase (PHGDH) acts as a metabolic...
by Acoustical Society of America Attaching microbubbles to macrophages can create high-resolution and sensitive tracking images useful for disease diagnosis. Credit: Ashley Alva Macrophages, a type of white blood cell, defend the body by engulfing and digesting foreign particles, such as bacteria, viruses, and dead cells. The immune cells also tend to accumulate in solid...
by Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) Electron microscopy images of lung macrophages in a normal mouse (left) and in a mouse deficient for mitochondrial oxidative phosphorylation (right). mn obtenida por microscopia electrónica de un macrófago pulmonar de un ratón normal (izquierda) y un macrófago con deficiencia en la fosforilación oxidativa mitocondrial (derecha)....
by Dresden University of Technology Alveolar macrophages are the immune cells that specifically live in the lung air sacs, here visible as red dots in an otherwise transparent mouse lung. Credit: Sara Gholamhosseinian Najjar and Michaela Burkon Macrophages are immune cells crucial for immune response, tissue repair, and the removal of cancer cells. Scientists see...
by Suzanne Leigh, University of California, San Francisco NP001 targets macrophages, a type of immune cell implicated in the destruction of neurons. Credit: Michael S. McGrath, MD, PhD A new drug has been found to slow or temporarily stall the progression of ALS (amyotrophic lateral sclerosis) in a select group of patients. The drug, a...
by La Jolla Institute for Immunology Credit: CC0 Public Domain An artery is not like a nose. Or is it? Scientists at La Jolla Institute for Immunology (LJI) have discovered that immune cells in arteries can “sniff” out their surroundings and cause inflammation. “Smelly molecules can be pro-inflammatory,” says study leader LJI Professor Klaus Ley,...
by The Korea Advanced Institute of Science and Technology (KAIST) Identification of distinct macrophage subtypes that trigger lung damage during SARS-CoV-2 infection. Credit: The Korea Advanced Institute of Science and Technology (KAIST) A KAIST immunology research team found that a specific subtype of macrophages that originated from blood monocytes plays a key role in the hyper-inflammatory response in...
RUDN UNIVERSITY IMAGE: RUDN University biologists discovered the way how macrophages (the cells of the “first line” immune response) respond to inflammation and identified how the immune response depends on their origin. It turned out that when exposed to an inflammatory stimulus, two opposing mechanisms are activated in macrophages simultaneously — inducing and inhibiting inflammation....
LUDWIG INSTITUTE FOR CANCER RESEARCH IMAGE: LUDWIG MEMORIAL SLOAN KETTERING’S INVESTIGATORS TAHA MERGHOUB, JEDD WOLCHOK, AND ASSISTANT ATTENDING PHYSICIAN ANDREW CHOW. CREDIT: LUDWIG CANCER RESEARCH JUNE 10, 2021, NEW YORK – A Ludwig Cancer Research study adds to growing evidence that immune cells known as macrophages inhabiting the body cavities that house our vital organs can aid...
Macrophages of the innate immune system, cells derived from monocytes, are involved in many processes in tissue beyond merely hunting down invading pathogens. They are also important to the processes of tissue maintenance regeneration following injury. Like all aspects of the immune system, macrophage behavior becomes dysregulated with age, a consequence of changes in the signaling environment that result from the accumulation...
