Illustration of T cell activation by APC (using CD4 T cells as an example). The TCR recognizes and binds to the pMHC complex presented by the APC. The coreceptor CD4 binds to the MHC class II molecule, generating the first signal, which induces T cell activation. Additionally, the binding of CD80 and CD86 on the...
Tag: <span>memory of innate immune cells</span>
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Mysterious fats reprogram the memory of innate immune cells
by Radboud University Graphical abstract. Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.113458 Researchers at Radboudumc have unveiled a fascinating connection between sphingolipids, mysterious fats named after the “Sphinx,” and the memory of cells from the innate immune system. This discovery provides new avenues for the development of innovative treatments for various diseases, including autoimmune disorders, cancer, cardiovascular...