by The Wistar Institute According to a study by The Wistar Institute, breast cancer cells starved for oxygen send out messages that induce oncogenic changes in surrounding normal epithelial cells. These messages are packaged into particles called extracellular vesicles (EVs) and reprogram mitochondrial shape and position within the recipient normal cells to ultimately promote deregulated...
A sizable portion of the variable efficacy of first generation stem cell therapies as presently practiced may be due to a poor quality of cells following expansion in culture. Regardless of quality, near all such cells die shortly after transplantation. Few clinics and few approaches to cell therapy lead to lasting survival and engraftment of...
by Vanderbilt University Medical Center Scientists at Vanderbilt University Medical Center (VUMC) and the Translational Genomics Research Institute (TGen) in Phoenix, Arizona, have discovered previously unreported genetic and cellular changes that occur in the lungs of people with pulmonary fibrosis (PF). Their findings, reported Wednesday, July 8, in the journal Science Advances, should aid the...
May 28, 2020 – For a while now, some plastic surgeons have been using stem cells to treat aging, sun-damaged skin. But while they’ve been getting good results, it’s been unclear exactly how these treatments – using adult stem cells harvested from the patient’s own body – work to rejuvenate “photoaged” facial skin. A new...
Durham, NC – A new study released today in STEM CELLS suggests for the first time that regulatory T-cells (Treg) induced by mesenchymal stromal cells can yield an abundant replacement for naturally occurring T-cells, which are vital in protecting the body from infection. Led by Rita I. Azevedo, Ph.D., at the Instituto de Medicina Molecular...
Zhi Liu, Yueqiao Xu, Yungao Wan, Jing Gao, Yanyan Chu & Jing Li Abstract Exosomes from bone marrow stem cells or cardiac progenitor cells can reduce apoptosis in myocardial cells after ischemia and reperfusion injury. However, there is little known about the effects of exosomes from adipose-derived stem cells (ADSCs), which are more abundant and have...
JUPITER, Fla.—New research conducted in the lab of Dr. Donald Phinney on the Florida campus of The Scripps Research Institute (TSRI) has identified factors critical to the differentiation of mesenchymal stem cells (MSCs), which are commonly used in stem cell therapies and clinical research. The study, published in the journal Cell Death and Differentiation, suggests a new approach...
Bone marrow-derived mesenchymal stem cells (MSCs) can be induced to make cartilage by incubating the cells with particular growth factors. Unfortunately, batches of MSCs show respectable variability from patient-to-patient. Therefore the growth factor-dependent method suffers from poor efficacy, limited reproducibility from batch-to-batch, and the cell types that are induced are not always terribly stable. Finding a better...
